BRUNO LUNENFELD


Reproductive Endocrinology

 

Career Highlights

  • M.D. Medical School, University Geneva, 1954
  • Visiting Scientist, Weizmann Institute of Science (1957-1961)
  • Director Institute of Endocrinology (1961-1992); Chairman Research and Ethical Committee (1977-1981) Sheba Medical Center
  • Since 1967 Consultant and Member of various committees, World Health Organization (WHO)
  • Joined Bar-Ilan University in 1967 and Founded and Headed the Dept. of Life Sciences in 1969
  • Full Professor 1969-1992
  • Professor Emeritus 1992 -present
  • Fellow Ad Eundum Royal College of Obstetrics and Gynecologists, U.K. (FRCOG) since 1981
  • Counselor Extern. Relations and Head Dept. Internat. Relations (1971-1985); Acting Chief Scientist (1984-1986), Ministry of Health
  • President - Israel Fertility Association (1979-1983); Israel Endocrine Society (since 1991)
  • Vice President Scientific Council, Israel Medical Association 1990-1997
  • Honorary Fellow of the American College of Obstetricians and Gynecology (FACOG hon.) 1991 and Honorary Member - Italian and French ,Polish Society of Gynecology; The German Endocrine Society; The Austrian Society of Fertility and Sterility.
  • Since 1989 Member of Executive Council Intern. Soc. of Gynecology. Endocrinology;
  • Since 1997 president of the International Society for the study of the aging male
  • Since 1997 Editor in Chief of "The Aging Male"
  • More then 500 publications, 359 in refereed journals, 112 Reports, Reviews and Chapters in Books and Author, Co-Author or Editor of 32 books.
  • Supervised 50 students and 4 are currently enrolled.

Research Areas

        Physiology and pathology of male and female reproduction. Stimulators, modulators and regulators of spermatogenesis and spermiogenesis. Stimulators, modulators, and regulators of folliculogenesis and ovulation. Mechanism of action of gonadotropins and growth factors on gene expression and steroidogenesis. Aging in men and women. Molecular mechanism of cell proliferation and cell death in hormone dependent tumors and in aging.

        Characterized the chemical and biological nature of human menopausal gonadotropins and discovered their use in male and female infertility. With his collaborators he established a diagnostic, therapeutic oriented, classification system for male and female infertility. Proposed guidelines for the management of infertility and designed effective treatment protocols. Research focused on the understanding of mechanisms controlling the hypothalamic-pituitary gonadal and adrenal axis and in the understanding of the nature, development and pathogenesis of diseases leading to functional abnormalities in this axis. Pioneered the use of GnRH analogues as stimulators and inhibitors of the gonads and of cells, tissues, organs or tumors depending on gonadal activity.

Selected publications

1.     Insler, V. and Lunenfeld, B. 1993 (2nd Edition). Infertility, Male and Female. Churchill Livingstone Edinburgh, London, Madrid, Melbourne, New York and Tokyo.

2.     Lunenfeld, B. and Insler, V. 1996. GnRH Analogues - The State of the Art 1996. The Parthenon Publishing Group, London, New York

3.     Lunenfeld, B. and Costrici, N. 1995. Endocrine and paracrine control of the estrogenic milieu in the growing follicle. Exp. Clin. Endocrinol. 103 (Suppl. 1): 10-10.

4.     Lunenfeld, B. and Lunenfeld, E. 1997. Gonadotropic preparations - lessons learned. Fertil. Steril. 67: 812-814.

5.     Lunenfeld, B. 1998. Aging male. (Editorial) The Aging Male 1: 1-7.