Physiology and pathology of male and female reproduction. Stimulators, modulators and regulators of spermatogenesis and spermiogenesis. Stimulators, modulators, and regulators of folliculogenesis and ovulation. Mechanism of action of gonadotropins and growth factors on gene expression and steroidogenesis. Aging in men and women. Molecular mechanism of cell proliferation and cell death in hormone dependent tumors and in aging.
Characterized the chemical and biological nature of human menopausal gonadotropins and discovered their use in male and female infertility. With his collaborators he established a diagnostic, therapeutic oriented, classification system for male and female infertility. Proposed guidelines for the management of infertility and designed effective treatment protocols. Research focused on the understanding of mechanisms controlling the hypothalamic-pituitary gonadal and adrenal axis and in the understanding of the nature, development and pathogenesis of diseases leading to functional abnormalities in this axis. Pioneered the use of GnRH analogues as stimulators and inhibitors of the gonads and of cells, tissues, organs or tumors depending on gonadal activity.
Insler, V. and Lunenfeld, B. 1993 (2nd Edition).
Infertility, Male and Female. Churchill Livingstone Edinburgh,
2. Lunenfeld, B. and Insler, V. 1996. GnRH Analogues - The State of the Art 1996. The Parthenon Publishing Group, London, New York
3. Lunenfeld, B. and Costrici, N. 1995. Endocrine and paracrine control of the estrogenic milieu in the growing follicle. Exp. Clin. Endocrinol. 103 (Suppl. 1): 10-10.
4. Lunenfeld, B. and Lunenfeld, E. 1997. Gonadotropic preparations - lessons learned. Fertil. Steril. 67: 812-814.
5. Lunenfeld, B. 1998. Aging male. (Editorial) The Aging Male 1: 1-7.