BAR-ILAN INSTITUTE OF NANOTECHNOLOGY & ADVANCED MATERIALS | 2019 ANNUAL REPORT

51 Prof. Ehud Banin The Mina & Everard Goodman Faculty of Life Sciences Member of BINA, Nano-Medicine & Nano-Clean-tech Center Research Areas • Bacterial biofilms • Nanoparticles with anti-biofilm properties • Bio-ethanol production Abstract The Biofilm Research Laboratory Our lab focuses on microbial biofilms, with the aim of understanding the signals and processes that promote biofilm formation, and finding new methods for treating biofilm-related medical, industrial and environmental problems. Nanotechnology can provide new opportunities for preventing and fighting biofilm-mediated problems via atomic-scale tailored nanomaterials. Our group is exploring the utility of potential antimicrobial / antibiofilm nanomaterials including metal fluorides, metal oxides and N-halamine nanoparticles which can provide long lasting rechargeable antibiofilm/antimicrobial activity. TEM micrographs of S. aureus (cyan) treated with the synthesized nano-particles (yellow). The nano particles target bacteria and mark them for destruction. Publications 2018 and 2019 • Shira Roth, Itzhak Zander, Yehudit Michelson, Yossi Ben-David, Ehud Banin and AmosDanielli, “Identification of protein-protein interactions using a magnetic modulation biosensing system”, Sensor & Actuators: B. Chemical 303, 2019 . • Hanna P.Steinmetz, Safra Rudnick-Glick, Michal Natan, Ehud Banin, Shlomo Margel, “Poly(styryl bisphosphonate) nanoparticles with a narrow size distribution: Synthesis, characterization and antibacterial applications”, European Polymer Journal, Volume 116, Pages 65- 73, 2019 . • Moorthy Maruthapandi, Michal Natan, Gila Jacobi, Ehud Banin, John H. T. Luong and Aharon Gedanken, “Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus of Colloidal Polydopamine Prepared by Carbon Dot Stimulated Polymerization of Dopamine”, Nanomaterials, 9(12), 1731, 2019 . • Michal Natan, Ori Gutman, Dekel Segev, Shlomo Margel and Ehud Banin, “Engineering Irrigation Drippers with Rechargeable N Halamine Nanoparticles for Antifouling Applications”, Appl. Mater. Interfaces, 11, 23584−23590, 2019 . • Diego Omar Sanchez Ramirez, Alessio Varesano, Riccardo Andrea Carletto, Claudia Vineis, Ilana Perelshtein, Michal Natan, Nina Perkas, Ehud Banin and Aharon Gedanken, “Antibacterial properties of polypyrrole-treated fabrics by ultrasound deposition”, Materials Science and Engineering: C Volume 102, Pages 164-170, 2019 . • Y. Ben-David, E. Zlotnik, I. Zander, G. Yerushalmi, S. Shoshani, and E. Banin, “SawR a new regulator controlling pyomelanin synthesis in Pseudomonas aeruginosa,” Microbiol. Res., vol. 206, pp. 91–98, 2018 . • Svirinovsky, I. Perelshtein, M. Natan, E. Banin, and A. Gedanken, “Imparting superhydrophobic and biocidal functionalities to a polymeric substrate by the sonochemical method,” Ultrason. Sonochem., vol. 44, pp. 398–403, 2018 . • N. Tal, S. Rudnick-Glick, I. Grinberg, M. Natan, E. Banin, and S. Margel, “Engineering of a New Bisphosphonate Monomer and Nanoparticles of Narrow Size Distribution for Antibacterial Applications,” ACS Omega, vol. 3, no. 2, pp. 1458–1469, Feb. 2018 . • T. Ulaganathan, W. Helbert, M. Kopel, E. Banin, and M. Cygler, “Structure-function analyses of a PL24 family ulvan lyase reveal key features and suggest its catalytic mechanism,” J. Biol. Chem., vol. 293, no. 11, pp. 4026–4036, 2018 . • TS Ulaganathan, E Banin, W Helbert, M Cygler, “Structural and functional characterization of PL28 family ulvan lyase NLR48 from Nonlabens ulvanivorans”, Journal of Biological Chemistry, jbc. RA118. 003659, 2018 . Prof. Eli Barkai Department of Physics Member of BINA, Nano-Photonics Center Research Areas • Dynamics of cold atoms in optical lattices. • Nano science: Blinking quantum dots. • Statistical physics: Foundations of weak ergodicity breaking. • Biophysics: dynamics of single molecules in live cells. • Dynamical systems: Infinite invariant measures and weak chaos. • Fractional kinetics. Fractals, • Single molecule photon statistics. Publications 2018 and 2019 • N. Leibovich, and E. Barkai, “Infinite ergodic theory for Heterogeneous Diffusion Processes”, Phys. Rev. E, 99, 042138, 2019 . • Alessandro Vezzani, EB, and Raffaella Burioni, “Single-big-jump Principle in physical modeling”, Phys. Rev. E. 100, 012108, 2019 . • Dror Meidan, EB, and David Kessler, “Running Measurement Protocol for the Quantum First-detection Problem”, J. Phys. A: Math. Theor. 52, 3454001, 2019 . • Aghion, D. A. Kessler, and E. Barkai, “From Non-Normalizable Boltzmann-Gibbs Statistics to Infinite-Ergodic Theory”, Phys. Rev. Lett. 122, 010601, 2019 .