BAR-ILAN INSTITUTE OF NANOTECHNOLOGY & ADVANCED MATERIALS | 2019 ANNUAL REPORT

62 properties of solid state systems. Using advanced nano -fabrication techniques, high precision electric measurements and low temperature techniques we study the properties of different geometries such as ultrathin films, nanowires, granular films and quantum dots focusing on disordered metals, superconductors and ferromagnets. Currently the group’s areas of interest include the disorder induced superconductor-insulator-transition, transport through nanoparticles and electron-glass properties in strongly disorder metals. Sketch of a gold nanoparticle connected to a ste of electrodes with variable coupling. Publications 2018 and 2019 • NA Lewellyn, IM Percher, JJ Nelson, J Garcia-Barriocanal, I Volotsenko, A Frydman, T Vojta, A M Goldman, “Quantum Superconductor-Metal Transitions in the Presence of Quenched Disorder”, Journal of Superconductivity and Novel Magnetism, 1-8, 2019 . • NA Lewellyn, IM Percher, JJ Nelson, J Garcia-Barriocanal, I Volotsenko, A Frydman, T Vojta, A M Goldman, “Infinite- randomness fixed point of the quantum superconductor-metal transitions in amorphous thin films”, Physical Review B 99 (5), 054515, 2019 . • T Nguyen, A Tavakoli, S Triqueneaux, R Swami, A Ruhtinas, J Gradel, P Garcia- Campos, K Hasselbach, A Frydman, B Piot, M Gibert, E Collin, O Bourgeois, “Niobium nitride thin films for very low temperature resistive thermometry”, Journal of Low Temperature Physics 197 (5-6), 348-356, 2019 . • D Dentelski, A Frydman, E Shimshoni, EG Dalla Torre, “Tunneling probe of fluctuating superconductivity in disordered thin films”, Physical Review B 97 (10), 100503, 2018 . • S Wissberg, A Frydman, B Kalisky, “Local view of superconducting fluctuations”, Applied Physics Letters 112 (26), 262602, 2018 . • A Roy, E Shimshoni, A Frydman, “Quantum Criticality at the Superconductor-Insulator Transition Probed by the Nernst Effect”, Physical review letters 121 (4), 047003, 2018 . • A Kremen, H Khan, YL Loh, TI Baturina, N Trivedi, A Frydman, B Kalisky, “Imaging quantum fluctuations near criticality”, Nature physics 14 (12), 1205, 2018 . Prof. Yuval Garini Department of Physics Member of BINA, Nano-Photonics Center Research Areas • Nano-biophysics • Study of protein-DNA interaction on the single-molecule level • Development of a novel optical method with a nanometer precision for detection of DNA-protein interactions • Study of the organization of the genome in the nucleus and its disruption in cancer cells Abstract Bio-Nano-Photonics TWe study biological systems by combining novel optical and biophysical methods. One of the main projects is to understand the organization of the genome in the nucleus. This is a complex challenge that requires a unified approach that combines physical understanding with biological knowledge. By using advanced live-cell imaging, we succeeded to identify an important mechanism and we continue our efforts to understand its details. We use single molecule methods, nano particles and advanced theoretical methods for understanding the properties of DNA and its interaction with proteins. The organization of the genome in the nucleus: Chromosomes stay in territories and they are not intermixed. We found that lamin A plays important role in maintaining this order. Publications 2018 and 2019 • Anat Vivante, Irena Bronshtein, and Yuval Garini, “Chromatin viscoelasticity measured by local dynamics analysis”, Biophysical Journal (in final publication procedures), 2019 . • Rakefet Ben-Yishay, Amir Mor, Amit Shraga, Asaf Ashkenazy-Titelman, Noa Kinor, Avital Schwed-Gross, Avi Jacob, Noga Kozer, Pramod Kumar, Yuval Garini, and Yaron Shav-Tal, “Imaging within single NPCs reveals NXF1’s role in mRNA export on the cytoplasmic side of the pore”, Journal of Cell Biology 218, 2962, 2019 . • David Zada, Irena Bronshtein, Tali Lerer-Goldshtein, Yuval Garini and Lior Appelbaum, “Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons”, Nature Communications, 10, 895, 2019 . • Anat Vivante, Eugene Brozgol, Irena Bronshtein, Vered Levi and Yuval Garini, “Chromatin dynamics governed by a set of nuclear structural proteins”, Genes Chromosomes and Cancer 58, 437-451, 2018 . • Noa Aloush, Tomer Schvartz, Andres I König, Sarit Cohen, Eugene Brozgol, Benjamin Tam, Dikla Nachmias, Oshrit Ben-David, Yuval Garini, Natalie Elia, Eyal Arbely, “Live cell imaging of bioorthogonally labelled proteins generated with a single pyrrolysine tRNA gene”, Scientific Reports 8, 14527, 2018 . • Efrat Roth, Alex Glick Azaria, Olga Girshevitz, Arkady Bitler and Yuval Garini, “Measuring the Persistence Length of Single-Stranded DNA Using a DNA Origami Structure”, Nano Letters, 18, 6703-6709, 2018 .