BAR-ILAN INSTITUTE OF NANOTECHNOLOGY & ADVANCED MATERIALS | 2019 ANNUAL REPORT

Publications 2018 and 2019 • DV Christensen, Y Frenkel, YZ Chen, YW Xie, ZY Chen, Y Hikita, A Smith, L Klein, HY Hwang, N Pryds, B Kalisky, “Strain-tunable magnetism at oxide domain walls”, Nature Physics 15 (3), 269, 2019 . • E Zion, N Haham, L Klein, A Sharoni, “Low temperature divergence in the AHE and AMR of ultra-thin Pt/Co/Pt trilayers”, Journal of Magnetism and Magnetic Materials 485, 314-319, 2019 . • H Nhalil, T Givon, PT Das, N Hasidim, V Mor, M Schultz, S Amrusi, L Klein, A Grosz, “Planar Hall effect magnetometer with 5 pT resolution”, IEEE Sensors Letters 3 (12), 1-4, 2019 . • A. Mordakhay, Y. Telepinsky, L. Klein, J. Shor, and A. Fish, “A Low Noise Low Offset Readout Circuit for Magnetic-Random- Access-Memory,” IEEE Trans. Circuits Syst. I Regul. Pap., vol. 65, no. 4, pp. 1224–1233, 2018 . • S Das, L Avraham, Y Telepinsky, V Mor, M Schultz, L Klein, “Magnetization switching of multi-state magnetic structures with current-induced torques”, Scientific Reports 8, 15160, 2018 . Prof. Lior Klein Head of Physics Department Member of BINA, Nano-Magnetism Center Research Areas • Magneto-transport in thin magnetic films (particularly ruthenates and manganites) • Anisotropic magnetoresistance and giant planar Hall effect • Current induced manipulation of domain walls • Macroscopic quantum tunneling • Transport properties of LAO/STO interfaces • Magnetic sensors and memory Abstract We integrate elliptical planar Hall effect (PHE) magnetometers with optimized, high permeability magnetic flux concentrators. The integrated magnetometers exhibit at room temperature an equivalent magnetic noise of ~ 5 pT/ ð Hz at 10 Hz, 7.4 pT/ ð Hz at 1 Hz, and better than 100 pT/ ð Hz at 10 mHz. The results constitute more than an order of magnitude improvement over previously reported state-of-the-art PHE magnetometers, and demonstrate, for the first time, the ability of a magneto-resistive sensor to match the performance of state- of-the-art, high-end flux-gate and miniature atomic magnetometers. A photo of the planar Hall effect sensor integrated with magnetic fluc concentrators and a graph showing the resolution of the sensor. Prof. Jean-Paul Lellouche Chemistry Department Member of BINA, Nano-Materials Center Research Areas • Functional electroconductive polymers (ECPs) and nano/microparticle fabrication -Functionalization/nanostructuration of polymeric films • Magnetically-responsive composite polymer-nanoparticles for ultrasensitive detection of DNA hybridization and drug release using combinatorial approaches • ECPs-microarrays for diagnostics • ECPs-biosensors/immunosensors • High-throughput screening of polymer- supported chiral catalysts 71 • (1,3)-dienyliron-carbonyl complexes in asymmetric synthesis • Selective deprotective chemistries of-OSiR3 ethers mediated by Vilsmeier- Haack reagents (kinetic resolutions/ deracemizations of meso compounds). • Functionalization of carbon nanotubes et use in self assembling systems/ composites materials. • Polymodal silica and silicon carbide nanoparticles for hard surfaces and their mode of functionalization using ECPs. Abstract Innovative Surface Engineering of Magnetic/Non-Magnetic Nanomaterials (Functional Inorganic TMDC Nanotubes, Nano-Diamonds (NDs) and Maghemite NPs for Gene Silencing, Photodynamic/ Photothermal Therapies, & Anti-Parasitic Bio-Activity) In our lab, we focused on both synthesis of functionalized magnetic NPs and surface modification/engineering of both tungsten disulfide nanotubes and Nano- Diamonds. These set of functional NPs are nontoxic/biocompatible and has a high potential as drug delivery systems, with an important capability of imaging (MRI, X-ray, Fluorescence, … etc.). So far, we focused on the following topics, the use of magnetically responsive NPs in cooperation with Photodynamic Therapy (PDT) drug towards higher drug accumulation by magnetic targeting and therefore, a much more effective PDT output. We also developed an effective innovative nanoscale Delivery System as anti-Leishmania drug, which is based on cerium cation/complex-doped maghemite nanoparticles (Ce· د -Fe 2 O 3 - NPs) that are coordinatively bound by both polyethylenemine (PEI) polymer and FDA-approved anti-leishmanial drug pentamidine. Novel surface engineering of nanodiamonds has been also innovatively discovered towards a preliminary wide range of biological and cosmetic applications. Moreover, novel functionalization of inorganic WS2 nanotubes with maghemite NPs resulted in an hybrid magnetic nanocomposite to improve anti-cancer treatment using photothermal therapy (PTT), as well as promoting nanomaterial reduced aggregation together with an additional ability for nanotube versatile second-step surface functionality/engineering.