BAR-ILAN INSTITUTE OF NANOTECHNOLOGY & ADVANCED MATERIALS | 2019 ANNUAL REPORT

Prof. Efrat Shimshoni Department of Physics Member of BINA, Nano-Magnetism Center Research Areas • Transport phenomena in low-dimensional and strongly correlated systems: 1. Low-dimensional superconductors 2. Spin chains 3. Quantum Hall systems. • Quantum phase transitions. • Dissipation in quantum systems. 86 Prof. Orit Shefi Faculty of Engineering Member of BINA, Nano-Medicine Center Research Areas • Neurobiological systems development: image processing and network analysis • Tissue Engineering: Developing skin grafts that enable reinnervation and regeneration • Developing devices for reagents delivery into live tissue at a microscopic resolution • Neuroprosthetic devices: Neuron-Chip interface Abstract Neuroengineering and Regeneration The lab’s research aims to unveil the basic mechanisms underlying neuronal development and leverages this knowledge towards obtaining improved methods for manipulating and promoting neuronal regeneration. Neurons develop into a wide-variety of shapes with important implications for neuronal function and connectivity. Following nerve injuries, the process of spontaneous nerve regeneration is incomplete. The lab’s approach is multidisciplinary and combines engineering, biology and material sciences, at the micro and nano scale. We analyze neuronal responses by implementing morphometric measurements, electrophysiological protocols, simulations and bioinformatics. Moreover, in order to target the nervous system and key injured, diseased tissues, we develop drug-delivery technologies, i.e. nanoparticles as carriers and mediators as well as nanoengineered platforms. The image shows florescent NPs injected into cells in the leech CNS ganglion via an electrode (shown near the orange injected neuron). Publications 2018 and 2019 • E Haimov-Talmoud, Y Harel, H Schori, M Motiei, A Atkins, R Popovtzer, JP Lellouche, O Shefi, “Magnetic Targeting of mTHPC to Improve the Selectivity and Efficiency of Photodynamic Therapy”, ACS applied materials & interfaces, 11, 49, 2019 . • N Zilony-Hanin, M Rosenberg, M Richman, R Yehuda, H Schori, M Motiei, S Rahimipour, A Groisman, E Segal, O Shefi, “Porous Materials: Neuroprotective Effect of Nerve Growth Factor Loaded in Porous Silicon Nanostructures in an Alzheimer’s Disease Model and Potential Delivery to the Brain (Small 45/2019)”, Small 15 (45), 2019 . • N Zilony-Hanin, M Rosenberg, M Richman, R Yehuda, H Schori, M Motiei, S Rahimipour, A Groisman, E Segal, O Shefi, “Neuroprotective Effect of Nerve Growth Factor Loaded in Porous Silicon Nanostructures in an Alzheimer’s Disease Model and Potential Delivery to the Brain”, Small, 15, 1904203, 2019 . • VB Kumar, R Kumar, O Friedman, Y Golan, A Gedanken, O Shefi, “One-Pot Hydrothermal Synthesis of Elements (B, N, P)-Doped Fluorescent Carbon Dots for Cell Labelling, Differentiation and Outgrowth of Neuronal Cells”, ChemistrySelect 4 (14), 4222- 4232, 2019 . • VB Kumar, R Kumar, A Gedanken, O Shefi, “Fluorescent metal-doped carbon dots for neuronal manipulations”, Ultrasonics sonochemistry 52, 205-213, 2019 . • K Baranes, D Hibsh, S Cohen, T Yamin, S Efroni, A Sharoni, O Shefi, “Comparing Transcriptome Profiles of Neurons Interfacing Adjacent Cells and Nanopatterned Substrates Reveals Fundamental Neuronal Interactions”, Nano letters 19 (3), 1451-1459, 2019 . • M Rosenberg, N Zilony, O Shefi, E Segal, “Designing Porous Silicon Films as Carriers of Nerve Growth Factor”, JoVE (Journal of Visualized Experiments), e58982, 2019 . • S. K. Yadav et al., “Elevated nuclear lamin A is permissive for granulocyte transendothelial migration but not for motility through collagen I barriers,” Journal of Leukocyte Biology, 2018 . • A. Ewing, I. S. Choi, W. Green, and O. Shefi, “Frontiers in Neurochemistry,” ChemPhysChem, Apr. 2018 . • E. Haimov, H. Weitman, S. Polani, H. Schori, D. Zitoun, and O. Shefi, “meso -Tetrahydroxyphenylchlorin-Conjugated Gold Nanoparticles as a Tool To Improve Photodynamic Therapy,” ACS Appl. Mater. Interfaces, vol. 10, no. 3, pp. 2319–2327, Jan. 2018 . • V. B. Kumar et al., “Ultrafine Highly Magnetic Fluorescent Ѕ -Fe 2 O 3 / NCD Nanocomposites for Neuronal Manipulations,” ACS Omega, vol. 3, no. 2, pp. 1897–1903, Feb. 2018 . • M Marcus, A Smith, A Maswadeh, Z Shemesh, I Zak, M Motiei, H Schori, S Margel, A Sharoni, O Shefi, “Magnetic Targeting of Growth Factors Using Iron Oxide Nanoparticles”, Nanomaterials 8 (9), 707, 2018 .