102 Prof. Sarid Ronit The Mina & Everard Goodman Faculty of Life Sciences Member of BINA Nano-Medicine Center Research Areas • The study of the etiology of cancer is critical to understanding how to prevent this disease and to improve treatment. • Exploring the Cellular and Viral Pathways of KSHV Infection Cycle and Pathogenesis • KSHV: Clinical and Epidemiological Studies • Drug Discovery, Design and Delivery Research for Infectious Disease Abstract Virology Research Kaposi’s sarcoma-associated herpesvirus (KSHV), also referred to as human herpesvirus-8 (HHV-8), is one of the few viruses proven to be associated with cancer in humans. It is causally associated with all clinical and epidemiological variants of Kaposi’s sarcoma as well as with two lymphoproliferative disorders: primary effusion lymphoma and a subset of multicentric Castleman’s disease. Like all other herpesviruses, primary infection with KSHV is followed by lifelong infection, with the potential for virus reactivation which enables virus spread and leads to an increased risk for disease development. Sarid’s group studies the cellular and viral signalling pathways that regulate the establishment of long-term latent infection and reactivation of KSHV. In addition, by examining viral-host protein interactions and the effects of viral proteins on cell proliferation, cell death, and signal transduction pathways, Sarid’s lab is characterizing the function and regulation of selected viral genes that are potentially involved in the pathogenesis of KSHV. Knowledge of the function of viral gene products is expected to help clarify the cellular pathways involved in KSHV-related infection and cancers as well as cancer in general. Publications 2020 and 2021 • Illouz, T., Biragyn, A., Weissberg, O., Gorohovski, A., Frenkel-Morgenstern, M., Merzon, E., Green, I., Lulita, F., FloresAguilar, L., Dierssen Sotos, M., Toma,I., Lifshitz, H., Gur, A., Eden, S., Antonarakis, S., Yu, E., Herault, Y., Potier, M.C., Roper, R., Sredni, B., Sarid, R., London., J., Mobley, W., Strydom, A., and Okun, E. “Susceptibility to emerging infections such as COVID-19 in adults with Down syndrome”. Neuromolecular Med, 2021; 23(4): 561–571. • Haddad, C.O., Kalt, I., Shovman, Y., Xia, L., Schlesinger, Y., Sarid, R. & Parnas, O. “Targeting the Kaposi’s sarcomaassociated herpesvirus genome with the CRISPR-Cas9 platform in latently infected cells”. Virology Journal, 2021. • Tomer Illouz, Arya Biragyn, Milana Frenkel-Morgenstern, Orly Weissberg, Alessandro Gorohovski, Eugene Merzon, Ilan Green, Florencia Iulita, Lisi FloresAguilar, Mara Dierssen, Ilario De Toma, Hefziba Lifshitz, Stylianos E Antonarakis, Eugene Yu, Yann Herault, Marie-Claude Potier, Alexandra Botté, Randall Roper, Benjamin Sredni, Ronit Sarid, Jacqueline London, William Mobley, Andre Strydom, Eitan Okun. “Specific susceptibility to COVID-19 in adults with Down Syndrome”. Neuromolecular Medicine, 2021. • Dror Meidan, Nava Schulmann, Reuven Cohen, Simcha Haber, Eyal Yaniv, Ronit Sarid, Baruch Barzel. “Alternating quarantine for sustainable epidemic mitigation”. Nature Communications, 2021. • Tomer Illouz, Arya Biragyn, Milana Frenkel-Morgenstern, Orly Weissberg, Alessandro Gorohovski, Eugene Merzon, Ilan Green, Florencia Iulita, Lisi FloresAguilar, Mara Dierssen, Ilario De Toma, Hefziba Lifshitz, Stylianos E Antonarakis, Eugene Yu, Yann Herault, Marie Claude Potier, Alexandra Botté, Randall Roper, Benjamin Sredni, Ronit Sarid, Jacqueline London, William Mobley, Andre Strydom, Eitan Okun. “Correction to: Specific Susceptibility to COVID-19 in Adults with Down Syndrome”. NeuroMolecular Medicine, 2021. • Chen Gam ze Letova, Inna Kalt, Meir Shamay, Ronit Sarid. “Latently KSHV-Infected Cells Promote Further Establishment of Latency upon Superinfection with KSHV”. International Journal of Molecular Sciences, 2021. • Sarid, R. “Investigating an emerging virus during a sudden pandemic outbreak”. Rambam Maimonides Med J, 2020. • Alkalay, E., Gam Ze Letova Refael, C., Sarid, R. and Shav-Tal, Y. “The sub-nuclear localization of RNA-binding proteins in KSHV-infected cells”. Cells, 2020. • Meidan, D., Schlmann, N., Cohen, R., Haber, S., Yaniv, E., Sarid, R. & Barzel, B. “Alternating quarantine for sustainable mitigation of COVID-19”. Nat Commun, 2020. Prof. Sebbah Patrick Department of Physics Member of BINA Nano- Photonics Center Research Areas • Experimental physics in Wave Propagation in Complex Media, • Light-Matter Interaction • Elastic waves in structures plates • Multiple Scattering, Anderson Localization • Nonlinear and Active Random Media, Random Lasers • Nonlinear Scattering, Instabilities • Speckle Statistics, Optical Singularities • Metamaterials • Microwave scattering and localization in disordered system. Abstract Mesoscopic optics and complex media Wave propagation in disordered complex media is a field of research with both fundamental important topics as well as a large range of applications related to imaging through opaque media, an important issue in medical imaging. Wave propagation in disordered media
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