103 The formation of stress granules in lung cell human organoids under oxidative stress. Red – stress granules. Cyan – nuclear RNA. Green – cell periphery marked by staining of actin filaments. Image by Avital GrossSchwed. Publications 2020 and 2021 • Daniela Dünn-Kittenplon, Asaf Ashkenazy-Titelman, Inna Kalt, Jean-Paul Lellouche, Yaron Shav-Tal, Ronit Sarid. “The Portal Vertex of KSHV Promotes Docking of Capsids at the Nuclear Pores”. Viruses, 2021. • Saady A, Varon E, Jacob A, Shav-Tal Y, and Fischer B. “Applying styryl quinolinium fluorescent probes for imaging of ribosomal RNA in living cells”. Dyes Pigments, 174, 107986, 2020. • Ashkenazy-Titelman A, Shav-Tal Y*, and Kehlenbach RH*. “Into the basket and beyond – the journey of mRNA through the nuclear pore complex”. Biochem J, 477, 23–44, 2020. • Saady A, Wojtyniak M, Varon E, Böttner V, Kinor N, Shav-Tal Y, Ducho C, and Fischer B. “Specific, sensitive, and quantitative detection of HER-2 mRNA breast cancer marker by fluorescent light-up hybridization probes”. Bioconjug. Chem., 31, 1188-1198, 2020. • Sebbag-Sznajder N, Brody Y, HochbergLaufer H, Shav-Tal Y, Sperling J, and Sperling R. “Dynamic supraspliceosomes are assembled on different transcripts regardless of their intron number and splicing state”. Front. Genet. 11, 409, 2020. • Hasenson SE, and Shav-Tal Y. “Speculating on the roles of nuclear speckles: how RNA-protein nuclear assemblies affect gene expression”. Bioessays, 42, e2000104, 2020. • Alkalay E, Gam Ze Letova Refael C, Shoval I, Kinor N, Sarid R, and Shav-Tal Y. “The sub-nuclear localization of RNA-binding proteins in KSHV-infected cells”. Cells 9, E1958, 2020. Publications 2020 and 2021 • Kun Tang, Chenni Xu, Sébastien Guenneau, and Patrick Sebbah. “Pulse dynamics of flexural waves in transformed plates”. Advanced Functional Materials 31 (15), 2009266, 2021. • Melanie Lebental, Patrick Sebbah. “Localized modes revealed in Random Lasers”. Optica 8 (8), 1033-1039, 2021. • Bhupesh Kumar, Ran Homri, Santosh K Maurya, Melanie Lebental, Patrick Sebbah. “Localized modes revealed in random lasers”. Optica, 2021. • K. Tang, M. Makwana, R. V. Craster, P. Sebbah. “Observations of symmetry induced topological mode steering in a reconfigurable elastic plate”. Phys. Rev. B 102, 214103, 2020. Prof. Sharoni Amos Department of Physics Member of BINA Nano-Magnetism Center Research Areas • Phase transitions on the nano-scale • Spintronics • New Temperature Coefficient of Resistance (TCR) materials • Organic/SC hybrid Publications 2020 and 2021 • Ganit Indech, Reut Plen, Dafna Levenberg, Naor Vardi, Michal Marcus, Alejandra Smith, Shlomo Margel, Orit Shefi, Amos Sharoni. “Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons”. Journal of Visualized Experiments: Jove, 2021. • Ilan Hakimi, Naor Vardi, Amos Sharoni, Michael Rosenbluh, Yosef Yeshurun. “Enhancement of photon detection in superconducting nanowire single photon detector exposed to oscillating magnetic field”. Applied Physics Letters, 2021. • Lior Shani, Philip Tinnefeld, Yafit Fleger, Amos Sharoni, Boris Ya Shapiro, Avner Shaulov, Oleg Gang, Yosef Yeshurun. “DNA origami based superconducting nanowires”. AIP Advances, 2021. • Michal Marcus, Ganit Indech, Naor Vardi, Itay Levy, Alexandra Smith, Shlomo Margel, Orit Shefi, Amos Sharoni. “Magnetic Organization of Neural Networks via Micro-Patterned Devices”. Adv. Mater. Interfaces, 2020, 7, 2000055. • Anatoly G. Shabalin, Elihu Anouchi, Nelson Hua, Yimin A. Wu, Martin V. Holt, Amos Sharoni, and Oleg G. Shpyrko. “Twinned nanostructure of VO2 thin films grown on r-cut sapphire”. Phys. Rev. B 102, 134106, 2020. Prof. Shav-Tal Yaron The Mina & Everard Goodman Faculty of Life Sciences Member of BINA Nano-Medicine Center Research Areas • Gene expression control in live cells • Live-cell imaging and RNA dynamics • Nuclear structure and function Abstract The studies in the Shav-Tal research group focus on fundamental regulatory points in the gene expression pathway and have centered on the mRNA molecule. We have examined co-transcriptional processing of mRNA at the site of transcription and its coupling to transcription; followed the dynamics of signaling pathways as they converge at the promoter and activate transcription; quantified the dynamic travels of mRNPs from the gene throughout the nucleoplasm and export through the NPC; and examined the fate of mRNA in the cytoplasm in P bodies and stress granules. We use live-cell measurements performed on fluorescence microscopes and include quantifications of the measured processes using singlemolecule analysis and mathematical modeling.
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