104 Prof. Shefi Orit Faculty of Engineering Member of BINA Nano-Medicine Center Research Areas • Neurobiological systems development: image processing and network analysis • Tissue Engineering: Developing skin grafts that enable reinnervation and regeneration • Developing devices for reagents delivery into live tissue at a microscopic resolution • Neuroprosthetic devices: Neuron-Chip interface Abstract Neuroengineering and Regeneration In our lab we aim to reveal basic mechanisms underlying neuronal development and network formation and to leverage this knowledge towards obtaining improved methods for promoting neuronal regeneration. Neurons develop into a wide-variety of shapes with important implications for neuronal function and connectivity. Following nerve injuries, the process of spontaneous nerve regeneration is incomplete. We develop engineered platforms at the micro and nano scale to support physically and chemically neuronal growth. We analyze the neuronal responses by implementing morphological measurements, electrophysiological protocols, simulations and bioinformatics. Moreover, in order to target the injured nervous system, we develop drug-delivery technologies. The image shows florescent NPs injected into cells in the leech CNS ganglion via an electrode (shown near the orange injected neuron). Publications 2020 and 2021 • Raj Kumar, Rossana Rauti, Denis Scaini, Merav Antman-Passig, Ohad Meshulam, Doron Naveh, Laura Ballerini, Orit Shefi. “Graphene-Based Nanomaterials for Neuroengineering: Recent Advances and Future Prospective”. Advanced Functional Materials, 2104887, 2021. • Merav Antman-Passig, Orit Shefi. “Engineering Oriented Scaffolds for Directing Neuronal Regeneration”. Virtual Prototyping & Bio Manufacturing in Medical Applications, 125-152, 2021. • Weiheng Xu, Sayli Jambhulkar, Dharneedar Ravichandran, Yuxiang Zhu, Mounika Kakarla, Qiong Nian, Bruno Azeredo, Xiangfan Chen, Kailong Jin, Brent Vernon, David G Lott, Jeffrey L Cornella, Orit Shefi, Guillaume Miquelard-Garnier, Yang Yang, Kenan Song. “3D PrintingEnabled Nanoparticle Alignment: A Review of Mechanisms and Applications”. Small, 2100817, 2021. • Weiheng Xu, Sayli Jambhulkar, Yuxiang Zhu, Dharneedar Ravichandran, Mounika Kakarla, Brent Vernon, David G Lott, Jeffrey L Cornella, Orit Shefi, Guillaume Miquelard-Garnier, Yang Yang, Kenan Song. “3D printing for polymer/particlebased processing: A review”. Composites Part B: Engineering, 109102, 2021. • Merav Antman-Passig, Jonathan Giron, Moshe Karni, Menachem Motiei, Hadas Schori, Orit Shefi. “Magnetic Assembly of a Multifunctional Guidance Conduit for Peripheral Nerve Repair”. Advanced Functional Materials, 2021. • Ariel Halevi, Sharon Cohen, Nairous Farah, Asaf Shoval, Orit Shefi, Yossi Mandel, Zeev Zalevsky, Nisan Ozana. “Remote optical sensing of neuronal tissue vibrations during regeneration”. Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVII …, 2020. • Marcus, M., Indech, G., Vardi, N., Levy, I., Smith, A., Margel, S., Shefi, O., Sharoni, A. “Magnetic Organization of Neural Networks via Micro-Patterned Devices”. Adv. Mater. Interfaces, 2020, 2000055. • Tiwari, A., Kumar, R., Shefi, O., Randhawa, J. “Fluorescent Mantle Carbon Coated Core-Shell SPIONs for Neuroengineering Applications”. ACS Appl. Bio Mater, 2020. • Cohen, S., Richter-Levin, A., Shefi, O. “Brief Electrical Stimulation triggers an effective regeneration of Leech CNS”. eNeuro, 2020, 7. • Hacohen, A., Jessel, H.R., Richter Levin, A., Shefi, O. “Patterning of Particles and Live Cells at Single Cell Resolution”. Micromachines, 2020, 11, 505. • Ofer, N., Shefi, O. & Yaari, G. “Axonal Tree Morphology and Signal Propagation Dynamics Improve Interneuron Classification”. Neuroinform, 2020. • Cohen, S., Sazan, H., Kenigsberg, A., Schori, H., Piperno, S., Shpaisman, H., Shefi, O. “Large-scale acoustic-driven neuronal patterning and directed outgrowth”. Scientific Report, 2020, 10, 4932. Prof. Shimshoni Efrat Department of Physics Member of BINA Nano-Magnetism Center Research Areas • Transport phenomena in low-dimensional and strongly correlated systems: 1. Low-dimensional superconductors 2. Spin chains 3. Quantum Hall systems • Quantum phase transitions • Dissipation in quantum systems Publications 2020 and 2021 • P Kubala, P Sierant, G Morigi, J Zakrzewski, J Kiethe, L Timm, H Landa, D Kalincev, TE Mehlstäubler, K Suthar, R Kraus, H Sable, D Angom, SB Jäger, L dell;Anna, A Konovalov, C Cormick, Condens Matter, K Biedroń, MJ Holland, F Petiziol, E Arimondo, L Giannelli, F Mintert, S Wimberger, P Wendebaum, BG Taketani, E Kajari, D Karevski, N Defenu, L Dell; Anna, T Enss, J Cooper, F Folz,L Wettmann, K Kruse, L Himbert, S Sharma, T Schmit, M Kastner, J Major, N Freitas, V Dunjko, T Calarco, CP Koch, S Ritter, JP
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