110 We have performed fundamental studies of the retinal chromophore in goal of understanding its color tuning mechanism, and isomerization properties. We are studying clusters of biomolecules and championing them as novel tools for action spectroscopy. We are also performing laboratory astrophysics measurements on small metal ions. Publications 2020 and 2021 • Y Toker, LH Andersen. “Gas-phase studies of the retinal protonated Schiff base chromophore”. The European Physical Journal D, 2021. • Henning Zettergren, Alicja Domaracka, Thomas Schlathölter, Paola Bolognesi, Sergio Díaz-Tendero, Marta Łabuda, Sanja Tosic, Sylvain Maclot, Per Johnsson, Amanda Steber, Denis Tikhonov, Mattea Carmen Castrovilli, Lorenzo Avaldi, S adia Bari, Aleksandar R Milosavljević, Alicia Palacios, Shirin Faraji, Dariusz G Piekarski, Patrick Rousseau, Daniela Ascenzi, Claire Romanzin, Ewa Erdmann, Manuel Alcamí,Janina Kopyra, Paulo Limão-Vieira, Jaroslav Kočišek, Juraj Fedor, Simon Albertini, Michael Gatchell, Henrik Cederquist, Henning T Schmidt, Elisabeth Gruber, Lars H Andersen, Oded Heber, Yoni Toker, Klavs Hansen, Jennifer A Noble, Christophe Jouvet, Christina Kjær, Steen Brøndsted Nielsen, Eduardo Carrascosa, James Bull, Alessandra Candian, Annemieke Petrignani. “Roadmap on dynamics of molecules and clusters in the gas phase”. The European Physical Journal D, 2021. • M. Kahana, L. Musbat, M. Nihamkin, Y. Diamant, S. Piperno, S. Itzhak, Y. Toker, “Harmonic height distribution in pickup spectroscopy within electrostatic ion beam traps”. Rev. Sci. Instrum. 91, 2020, 043301. Dr. Tzur Amit The Mina & Everard Goodman Faculty of Life Sciences Member of BINA Nano-Medicine Center Research Areas • The mammalian cell cycle • Cell growth and size homeostasis of proliferating cells Publications 2020 and 2021 • Danit Wasserman, Sapir Nachum, Meirav Noach-Hirsh, Naomi Auerbach, Evelin Sheinberger-Chorni, Taylor P Enrico, Roxane Lahmi, Michael J Emanuele, Amit Tzur. “Elucidating Human Mitosis Using an Anaphase-Like Cell-Free System”. Cell Cycle Oscillators, 143-164, 2021. • E Panet, SHO Shalom, O Kraus, I Shoval, R Lahmi, H Shapiro, A Tzur. “Use of cell doublets for studying cytokinesis regulation reveals a new form of cytokinesis regression”. Research Square, 27 Jul 2021. • Wasserman D, Nachum S, Noach-Hirsh M, Auerbach N, Sheinberger-Chorni E, Enrico TP, Lahmi R, Emanuele MJ, Tzur A. “Elucidating human mitosis using an anaphase-like cell-free system”. Methods Mol Biol. Chapter, 2020. • Emanuele MJ, Enrico TP, Mouery R, Wasserman D, Nachum S, Tzur A. “Complex cartography: E2F transcriptional control by Cyclin F and ubiquitin”. Trends Cell Biol, 2020. • Wasserman D, Nachum S, Cohen M, Enrico TP, Noach-Hirsh M, Parasol J, Zomer-Polak S, Auerbach N, SheinbergerChorni E, Nevenzal H, Levi-Dadon N, Wang X, Lahmi R, Michaely E, Gerber D, Emanuele MJ, Tzur A. “Cell cycle oscillators underlying orderly proteolysis of E2F8”. Mol Biol Cell, 2020. Prof. Weiss Shimon Department of Physics BIU Department of Chemistry and Biochemistry UCLA Member of BINA Nano-Medicine & Nano-Photonic Center Research Areas • Single molecule detection and spectroscopy • Dynamic structural/molecular biology, • Protein folding, protein-protein and protein-DNA interactions • Novel Bio-Nano-Technology probes, semiconductor nanocrystals, quantum dots, semiconductor nanocrystals voltage sensors • Fluorescence microscopy/spectroscopy, super resolution microscopy • Mesoscopic systems Abstract Voltage Sensing Nano Particle as an Optical Tool for Electrical Potential Activity in Neurons Voltage sensing nanoparticles (vsNPs) have been developed for non invasive optical recording of membrane potential at the single particle and nanoscale level, at multiple sites, in a large field-of-view. vsNPs allow for ‘pointy’, single particle voltage detection. However, they still face challenges and additional improvements are needed before this new generation of sensors can be widely translated to neurophysiological applications. We developing targetable membrane potential nanosensors (MPNs) that optically and non-invasively record MPs at multiple sites in a large field of-view (FoV) of primary cultured neurons with single-particle brightness and voltage sensing capacity at the nanoscale. We searching for the ultimate nanometer size particle suitable for site specific voltage membrane sensing on the nanoscale. We therefore studied and developing different systems.
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