113 Prof. Zaban Arie President of BIU Department of Chemistry Member of BINA ex-Director of BINA Nano-Energy Center Research Areas • Solar energy • Dye Sensitized Solar Cells (DSSC) • Nanoporous wide band-gap semiconductor electrodes, single material and core-shell systems • Nanosize wide band-gap semiconductors with controlled properties via surface control • Low cost spectral splitting for multibandgap photovoltaics • Interdigitated organic/inorganic nanosize layers towards the development of low cost “plastic” solar cells and smart polymers Abstract The Cahen-Zaban group studies (opto) electronic materials, esp. for Photovoltaics. A major tool is combinatorial material science to answer renewable energy's need for new materials, i.e., to explore compounds with unique characteristics with current focus on halide perovskites and charge-selective metal oxides. Further interests are in Biomolecules, esp. proteins as electronic materials for future bioelectronics. Work-flow diagram of the combinatorial material science scheme Publications 2020 and 2021 • Lior Shani, Aaron N. Michelson, Brian Minevich, Yafit Fleger, Michael Stern, Avner Shaulov, Yosi Yeshurun, Oleg Gang. “3D superconducting nanoscale architectures assembled by DNA”. Nature Communication, 2020. • John Linden, Yasha Nikulshin , Alex Friedman, Yosef Yeshurun and Shuki Wolfus. “Phase Coupling Effects in ThreePhase Inductive Fault-Current Limiter Based on Permanent Magnets”. IEEE Transactions on Magnetics, 56, 8600107 2020. Dr. Yissachar Nissan The Mina & Everard Goodman Faculty of Life Sciences Member of BINA Nano-Medicine Research Areas • Host-Microbiome Interactions in Health and Disease Abstract Host-Microbiome Interactions in Health and Disease Our lab studies how cells of the immune system in the gut interact with their environment - specifically the gut microbes (microbiota) and the enteric nervous system – and how these interactions control the balance between inflammation and tolerance, in health and disease. For this purpose, we combine microscopy, genomics, and molecular biology, with a unique gut organ culture system which we have recently developed. This system allows us to perform experiments which cannot be readily performed otherwise and has recently led us to discover that enteric neurons mediate microbiotainduced T-cells development in the gut. Dissecting the molecular mechanisms underlying neuro-immune-microbiome cross-talks may lead to the development of microbiome- based, personalized therapy for inflammatory and autoimmune diseases. Publications 2020 and 2021 • Mara Gagliardi, Romina Monzani, Nausicaa Clemente, Luca Fusaro, Valentina Saverio, Giovanna Grieco, Elżbieta Pańczyszyn, Nissan Yissachar, Francesca Boccafoschi, Marco Corazzari. “A Gut-Ex-Vivo System to Study Gut Inflammation Associated to Inflammatory Bowel Disease (IBD)”. Biology, 2021. • Shalhevet Azriel, Hadar Bootz, Alon Shemesh, Sivan Amidror, Nissan Yissachar. “An Intestinal Gut Organ Culture System for Analyzing HostMicrobiota Interactions”. Journal of Visualized Experiments: Jove, 2021. • Mara Gagliardi, Nausicaa Clemente, Romina Monzani, Luca Fusaro, Eleonora Ferrari, Valentina Saverio, Giovanna Grieco, Elżbieta Pańczyszyn, Flavia Carton, Claudio Santoro, Sara Del Mare-Roumani, Sivan Amidror, Nissan Yissachar, Francesca Boccafoschi, Silvia Zucchelli, Marco Corazzari. “Gut-Ex-Vivo system as a model to study gluten response in celiac disease”. Cell Death Discovery, 2021. • Grosheva I, Zheng D, Levy M, Polansky O, Lichtenstein A, Golani O, Dori-Bachash M, Moresi C, Shapiro H, Del Mare-Roumani S, Valdes-Mas R, He Y, Karbi H, Chen M, Harmelin A, Straussman R, Yissachar N, Elinav E, and Geiger B. “High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function”. Gastroenterology, 2020. • Chen Z, Zhou R, Zhang Y, Hao D, Wang Y, Huang S, Liu N, Xia C, Yissachar N, Huang F, Chu Y, and Yan D. “β-Arrestin 2 Quenches TLR Signaling to Facilitate the Immune Evasion of EPEC”. Gut Microbes, 1:1423-1437, 2020. • Duscha A*, Gisevius B*, Hirschberg S*, Yissachar N*, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA, Gold R, and Haghikia A. “Propionic acid shapes the course of multiple sclerosis by a distinct immunomodulatory mechanism”. Cell, 180(6):1067-1080, 2020. (* Indicates equal contribution) • Yissachar N. “Ménage à trois: regulation of host immunity by enteric neuroimmune- microbiota cross talks”. Current Opinion in Neurobiology, 62:26-33, 2020.
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