69 Prof. Berkovits Richard Department of Physics Member of BINA Nano-Magnetism Center Research Areas • Quantum and statistical mechanics in meso- and nanosystems. • Physical properties of quantum dots and nanoparticle (0D), quantum wires (1D) and quantum well (2D). • Coulomb blockade and magnetization of restricted geometries. • Interaction and disorder effects in nano and mesoscopic systems: persistent currents, quantum chaos, Kondo and im • Quantum phase transitions in low dimensions, many-particle localization, entanglement and networks. Abstract Quantum and statistical mechanics in meso- and nanosystems. Extracting many-particle entanglement entropy from observables using supervised machine learning Publications 2020 and 2021 • Richard Berkovits. “Probing the metallic energy spectrum beyond the Thouless energy scale using singular value decomposition”. Physical Review B, 2021. • Richard Berkovits. “Super-Poissonian behavior of the Rosenzweig-Porter model in the nonergodic extended regime”. Phys. Rev. B 102, 165140, 2020. • Yishai Schreiber and Richard Berkovits, “Entanglement between Distant Regions in Disordered Quantum Wires”. Advanced Quantum Technologies 3 (4), 1900113, 2020. • Marcello Calvanese Strinati, Richard Berkovits, and Efrat Shimshoni. “Emergent bosons in the fermionic two-leg flux. Physical Review B 100 (24), 245149, 2020. • A Roy, Y Wu, R Berkovits, A Frydman. “Universal Voltage Fluctuations in Disordered Superconductors”. Physical Review Letters 125 (14), 147002, 2020. Dr. Bretler Sharon Scanning Electron Microscopy Unit Member of BINA staff Publications 2020 and 2021 • T. Iline-Vul, S. Bretler, S. Cohen, I. Perelshtein, N. Perkas, A. Gedanken, & S. Margel. “Engineering of superhydrophobic silica microparticles and thin coatings on polymeric films by ultrasound irradiation”. Materials Today Chemistry, 21, 100520, 2021 . • U. Bretler, S. Shimron, S. Bretler, Y. Yizhakov. “Characterization and Forensic Identification of a Novel Cocaine Charcoal Smuggling Matrix”. Forensic Science International, 2021, 111104, ISSN 03790738. • S. Bretler, N. Kanovsky, T. Iline-Vul, S.Cohen, S. Margel. “In-situ thin coating of silica micro/nano-particles on polymeric films and their anti-fogging application.” Colloids and Surfaces A: Physicochemical and Engineering Aspects 607, 2020: 125444. Prof. Brodie Chaya The Mina & Everard Goodman Faculty of Life Sciences Dept. of Neurosurgery, Henry Ford Hospital Member of BINA Nano-Medicine Center Research Areas • Studying the role of protein kinase C in the regulation of cellular growth, differentiation and apoptosis. • Studying the molecular mechanisms underlying the development of brain tumors: Exploring signal transduction pathways involved in glial cell transformation and identification of novel proteins and genes expressed in brain tumors; development of in vivo and in vitro models of brain tumors; development of novel diagnostic and therapeutic approaches for brain tumors; studying the role of stem cells in the development of brain tumors and their use as a vehicle in gene therapy. • The bi-directional interaction between the nervous and immune systems and the role of this interaction in the function of neuronal and glial cells during physiological and pathological conditions. Abstract Topic 1 Cancer stem cells from brain tumors GBMs contain a small subpopulation of cancer cells called glioma stem cells (GSCs) that are characterized by the ability to selfrenew, exhibit multi-lineage differentiation potential and the generation of xenografts that recapitulate the parental tumor. GSCs are resistant to conventional therapies as compared with differentiated tumor cells, and therefore remain at the tumor site following resection, which eventually leads to tumor recurrence. Therefore, delineating the cellular and molecular mechanisms that control the stemness and functions of GSCs is essential for identifying therapeutic approaches to selectively target GSCs. We have been demonstrated the role of autophagy in determining the radiation resistance of GSCs and identified specific signaling pathways such as the miR-137-
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