76 Prof. Fixler Dror Faculty of Engineering Director of BINA Nano Photonics Center Research Areas • Fluorescence lifetime and anisotropy decay • Fluorescence lifetime imaging (FLIM) • Biological imaging based on fluorescence parameters • Super resolution • Light-tissue interaction Abstract Nano photonics, Fluorescence Imaging and Microscopy Research Fixler’s lab deals with theoretical and practical models for reconstructing the optical properties of participating media by nano photonic tools. Our theory is based on a robust generalization of the diffusion theory; Gerchberg-Saxton algorithm; dipole-dipole approximation and other methods. On the practical side we use lasers, LEDs and microscopes. Diffusion reflectance method combined with targeted gold nanorod contrast agents distinguishing with high specificity between the healthy and the abnormal sites in the tissue. Publications 2020 and 2021 • Shiran Sudri, Hamootal Duadi, Florin Altman, Irit Allon, Ariel Ashkenazy, Ruchira Chakraborty, Ilya Novikov, Dror Fixler, Abraham Hirshberg. “Diffusion Reflection Method for Early Detection of Oral Squamous Cell Carcinoma Specifically Targeted by Circulating Gold-Nanorods Bio-Conjugated to AntiEpidermal Growth Factor Receptor”. International Journal of Nanomedicine, 2021. • Dror Fixler, Hamootal Duadi, Idit Ferder. “Influence of detector size and positioning on near-infrared measurements and iso-pathlength point of turbid materials”. Frontiers in Physics, 2021. • S.V. Zar’kov, Yu.A. Avetisyan, A.N. Yakunin, I.G. Meerovich, D. Fixler, A.P. Savitsky and V.V. Tuchin. “Interaction of laser radiation and complexes of gold nanoparticles linked with proteins”. Quantum Electronics 51 (1), 52, 2021. • S Pawar, H Duadi, Y Fleger, D Fixler. “Carbon Dots-Based Logic Gates”. Nanomaterials, 2021, 11, 232. • Małgorzata Szczerska, Monika Kosowska, Paulina Listewnik, Michał Rycewicz, Mikhael Bechelany, Yafit Fleger, Dror Fixler, Paweł Jakóbczyk. “Diamond protection for reusable ZnO coated fiber-optic measurement head in optoelectrochemical investigation of bisphenol A”. Measurement, 2021. • Haim Feldman, Mark A Iron, Dror Fixler, Sergei Moshkov, Naomi Zurgil, Elena Afrimzon, Mordechai Deutsch. “Fluorophore spectroscopy in aqueous glycerol solution: the interactions of glycerol with the fluorophore”. Photochemical & Photobiological Sciences, 2021. • Marianna Beiderman, Ariel Ashkenazy, Elad Segal, Menachem Motiei, Adi Salomon, Tamar Sadan, Dror Fixler, Rachela Popovtzer. “Optimization of Gold Nanorod Features for the Enhanced Performance of Plasmonic Nanocavity Arrays”. ACS Omega, 2021. • Inbar Yariv, S riram Kannan, Yifat Harel, Esthy Levy, Hamootal Duadi, Jean-Paul Lellouche, Shulamit Michaeli, Dror Fixler. “Iterative optical technique for detecting anti-leishmania nanoparticles in mouse lesions”. Biomedical Optics Express, 2021. • Idit Feder, Hamootal Duadi, Dror Fixler. “Effect of Spatial Modulated Light on Position of Self-Calibration Point”. IEEE Photonics Journal, 2021. • S Sudri, I Allon, I Abu El-Naaj, D Fixler, A Hirshberg. “Gold nanoparticles reflectance discriminate benign from malignant salivary gland neoplasma”. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2021. • Channa Shapira, Inbar Yariv, Rinat Ankri, Hamootal Duadi, Dror Fixler. “Effect of optical magnification on the detection of the reduced scattering coefficient in the blue regime: theory and experiments”. Optics Express, 2021. • Pavitra Sokke Rudraiah, Hamootal Duadi, Dror Fixler. “Extraction of optical properties from a turbid medium using fiber probe for spectral and spatial diffuse reflectance measurement”. OSA Continuum, 2021. • Shweta Pawar, Hamootal Duadi, Yafit Fleger, Dror Fixler. “Carbon Dots-Based Logic Gates”. Nanomaterials 11 (1), 232, 2021. • M Kosowska, D Majchrowicz, M Ficek, P Wierzba, Y Fleger, D Fixler, Małgorzata Szczerska. “Nanocrystalline diamond sheets as protective coatings for fiberoptic measurement head”. Carbon, 2020. • Ruchira Chakraborty, D. Leshem-Lev, R. Kornowski, Dror Fixler. “The Scattering of Gold Nanorods Combined with Differential Uptake, Paving a New Detection Method for Macrophage Subtypes Using Flow Cytometery”. Nano Letters, 2020. • M. Kosowska, P. Listewnik, D. Majchrowicz, M. Rycewicz, M. Bechelany, Y. Fleger, Dror Fixler, M. Szczerska. “Microscale diamond protection for a ZnO coated fiber optic sensor”. Scientific Reports (Nature publications). 10:19141, 2020. • Idit Feder, Hamootal Duadi, Dror Fixler. “Single wavelength measurements of absorption coefficient based on isopathlength point”. Biomedical optics express, 11(10) 5760-5771, 2020. • Inbar Yariv, Hamootal Duadi, and Dror Fixler. “Depth scattering characterization of multi-layer turbid media based on iterative multi-plane reflectance measurements”. IEEE Photonics Journal, 12(5) 3700713, 2020. • M. Beiderman, A. Ashkenazy, M. Motiei, T. Sadan, A. Salomon, S. Rahimipour, R. Popovtzer and D. Fixler. “Gold NanorodBased Bio-Barcode Sensor Array for Enzymatic Detection in Biomedical Applications”. ACS Appl. Nano Mater., 3(8) 8414-8423, 2020. • Eran A. Barnoy, Rachela Popovtzer and Dror Fixler. “Fluorescence for biological logic gates”. Journal of biophotonics, 2020. • Andreas Walter, Perrine Paul-Gilloteaux, Birgit Plochberger, Ludek Sefc, Paul Verkade, Julia Mannheim, Paul Slezak, Angelika Unterhuber, Martina MarchettiDeschmann, Manfred Ogris, Katja Bühler, Dror Fixler, Stefan Geyer, Wolfgang Weninger, Martin Glösmann, Stephan Handschuh, Thomas Wanek. “Correlated Multimodal Imaging in Life Sciences: Expanding the Biomedical Horizon”. Frontiers in Physics, 8 Article 47, 2020.
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