86 Delivery System as anti-Leishmania drug, which is based on cerium cation/ complex-doped maghemite nanoparticles (Ce·ɣ-Fe2O3-NPs) that are coordinatively bound by both polyethylenemine (PEI) polymer and FDA-approved antileishmanial drug pentamidine. Novel surface engineering of nanodiamonds has been also innovatively discovered towards a preliminary wide range of biological and cosmetic applications. Moreover, novel functionalization of inorganic WS2 nanotubes with maghemite NPs resulted in an hybrid magnetic nanocomposite to improve anti-cancer treatment using photothermal therapy (PTT), as well as promoting nanomaterial reduced aggregation together with an additional ability for nanotube versatile second-step surface functionality/engineering. Publications 2020 and 2021 • Tzuriel Levin, Yakir Lampel, Gaya Savyon, Esthy Levy, Yifat Harel, Yuval Elias, Moshe Sinvani, Iftach Nachman & JeanPaul Lellouche. “Innovative functional polymerization of pyrrole-N-propionic acid onto WS2 nanotubes using ceriumdoped maghemite nanoparticles for photothermal therapy”. Scientific Reports volume 11, Article number: 18883, 2021. • Sriram Kannana, YifatHarel, EsthyLevy, Avishay Dolitzky, Assaf Sagivd Saurav, Aryal Laila Suleman, Jean-Paul Lellouche, Shulamit Michaeli. “Nano-Leish-IL: A novel iron oxide-based nanocomposite drug platform for effective treatment of cutaneous leishmaniasis”. Journal of Prof. Lellouche Jean-Paul Department of Chemistry Member of BINA Nano-Materials Center Research Areas • Functional electroconductive polymers (ECPs) and nano/microparticle fabrication - Functionalization/nanostructuration of polymeric films • Magnetically-responsive composite polymer-nanoparticles for ultrasensitive detection of DNA hybridization and drug release using combinatorial approaches • ECPs-microarrays for diagnostics • ECPs-biosensors/immunosensors • High-throughput screening of polymersupported chiral catalysts • (1,3)-dienyliron-carbonyl complexes in asymmetric synthesis • Selective deprotective chemistries ofOSiR3 ethers mediated by VilsmeierHaack reagents (kinetic resolutions/ deracemizations of meso compounds). • Functionalization of carbon nanotubes et use in self assembling systems/ composites materials. • Polymodal silica and silicon carbide nanoparticles for hard surfaces and their mode of functionalization using ECPs. Abstract Innovative Surface Engineering of Magnetic/Non-Magnetic Nanomaterials (Functional Inorganic TMDC Nanotubes, Nano-Diamonds (NDs) and Maghemite NPs for Gene Silencing, Photodynamic/ Photothermal Therapies, & Anti-Parasitic Bio-Activity) In our lab, we focused on both synthesis of functionalized magnetic NPs and surface modification/engineering of both tungsten disulfide nanotubes and NanoDiamonds. These set of functional NPs are nontoxic/biocompatible and has a high potential as drug delivery systems, with an important capability of imaging (MRI, X-ray, Fluorescence, … etc.). So far, we focused on the following topics, the use of magnetically responsive NPs in cooperation with Photodynamic Therapy (PDT) drug towards higher drug accumulation by magnetic targeting and therefore, a much more effective PDT output. We also developed an effective innovative nanoscale Controlled Release. Volume 335, 10 July 2021, Pages 203-215. • Anurag Kumar, Yifat Harel, Jean-Paul (Moshe) Lellouche & Suman L. Jain. “Catalytic Application of Ceric Ammonium Nitrate-Stabilized Maghemite Nanoparticles (CAN-γ-Fe2O3) for Ultrasound Assisted Synthesis of β-Amino Derivatives”. Journal of Inorganic and Organometallic Polymers and Materials volume 31, pages 3213–3219 2021. • Anurag Kumar, Yifat Hare, Jeanpaul Lellouche, Suman L. Jain. “Novel Ceric Ammonium Nitrate-Stabilized Maghemite Nanoparticles (CAN-γ-Fe2O3) for Ultrasound Assisted Synthesis of β-Amino Derivatives”. ResearchSqure, 2021. • Daniela Dünn-Kittenplon, Asaf Ashkenazy-Titelman, Inna Kalt, Jean-Paul Lellouche, Yaron Shav-Tal and Ronit Sarid. “The Portal Vertex of KSHV Promotes Docking of Capsids at the Nuclear Pores”. Viruses, 2021, 13(4), 597. • Tzuriel Levin, Yifat Harel, JeanPaul Lellouche, Alexey Moshkovich, Igor Lapsker, Alex Laikhtman and Lev Rapoport. “Tungsten Disulfide Inorganic Nanotubes Functionalized by PTFE for Friction Application”. Lubricants, 2021, 9(8), 78. • Inbar Yariv, Sriram Kannan, Yifat Harel, Esthy Levy, Hamootal Duadi, Jean-Paul Lellouche, Shulamit Michaeli, and Dror Fixler. “Iterative optical technique for detecting anti-leishmania nanoparticles in mouse lesions”. Biomedical Optics Express Vol. 12, Issue 7, pp. 4496-4509, 2021. • Itshak-Levy, D., Israel, L. L., Schmerling, B., Kannan, S., Sade, H., Michaeli, S., Lellouche, J.-P.. “Disaggregation, Stabilization, and Innovative Functionalization/Surface Engineering of Detonation Nanodiamonds via Ultrasonication-Promoted Ceric Ammonium Nitrate Treatment”. Diamonds & Related Materials, 2020, 104, 107738. • Q. Palomar, C. Gondran, J.-P. Lellouche, S. Cosnier, & M. Holzinger. “Functionalized Tungsten disulfide nanotubes for Dopamine and Catechol detection in a Tyrosinase-based Amperometric Biosensor Design”. J. Materials Chemistry B, 2020, 8(16), 3566-3573. • Narsingh R. Nirala, Y. Harel, J.-P. Lellouche, & G. Shtenberg. “Ultrasensitive haptoglobin biomarker detection based on amplified chemiluminescence of magnetite nanoparticles”. Journal of NanoBiotechnology, 2020, 18(1), 6. • Jyoti Patel, Bhawana Jain, Ajaya K. Singh*, Md. Abu Bin Hasan Susan, Lellouche J.-P., Mn-Doped ZnS. “Quantum dots – An Effective Nanoscale Sensor”. Microchemical Journal, 2020, 155, 104755.
RkJQdWJsaXNoZXIy NDU2MA==