2021 ANNUAL REPORT | Bar-Ilan Institute of Nanotechnology & Advanced Materials

98 Perelshtein, Ilana; Aviv, Hagit; Tischler, Yaakov R.; Nessim, Gilbert. “Higher Ultrasonic Frequency Liquid Phase Exfoliation Leads to Larger and Monolayer to Few-Layer Flakes of 2D Layered Materials”. Langmuir, 2021., 37, 15, 4504– 4514 • Slavin, Yael; Ivanova, Kristina; Hoyo, Javier; Perelshtein, Ilana; Owen, Gethin; Haegert, Anne; Lin, Yen-Yi; Le Bian, Stephane; Gedanken, A; Hafeli, Urs; Tzanov, Tzanko; Bach, Horacio. “Novel lignin-capped silver nanoparticles against multidrug-resistant bacteria”. ACS Applied Materials & Interfaces, 2021, 13, 19, 22098–22109. • T. Iline-Vul, S. Bretler, S. Cohen, I. Perelshtein, N. Perkas, A. Gedanken and S. Margel. “Engineering of Superhydrophobic Silica Microparticles and Thin Coatings on Polymeric Films by Ultrasound Irradiation”. Mater. Today Chem, 2021, 21, 100520. • Tali Sharabani, Sarah Taragin, Ilana Perelshtein, Malachi Noked, and Ayan Mukherjee. “Interfacial Engineering of Na3V2(PO4)2F3 Hollow Spheres through Atomic Layer Deposition of TiO2: Boosting Capacity and Mitigating Structural Instability”. Small, 2021, 2104416. • Aleksandra Ivanova, Kristina Ivanova, Ilana Perelshtein, Aharon Gedanken, Katerina Todorova, Rositsa Milcheva, Petar Dimitrov, Teodora Popova, Tzanko Tzanov. “Sonochemically engineered nano-enabled zinc oxide/amylase coatings prevent the occurrence of catheter-associated urinary tract infections”. Materials Science and Engineering: C. 131. 2021 112518. • Sadhanala, HK; Perelshtein, I; Gedanken, A. “Boosting Electrocatalytic Hydrogen Evolution of Nickel foam Supported Nickel Hydroxide by Ruthenium Doping”. ChemistrySelect, 2020, 5 (31), 9626-9634. • A. Mukherjee, R. Sharma, T. Sharabani, I. Perelshtein and M. Noked. “High rates Na0.7Li2.3V2(PO4)2F3 hollow sphere as cathode for lithium ion battery, prepared via solvothermal and electrochemical ion exchange”. Journal of Materials Chemistry A, 2020, 8 (40), 21289-21297. • Iline-Vul, Taly; Nanda, Raju; Mateos, Borja; Hazan, Shani; Matlahov, Irina; Perelshtein, Ilana; Keinan-Adamsky, Keren; Althoff-Ospelt, Gerhard; Konrat, Robert; Goobes, Gil. “Osteopontin regulates biomimetic calcium phosphate crystallization from disordered mineral layers covering apatite crystallite”. Scientific reports, 2020, 10 (1), 15722. • Harika, VK; Sadhanala, HK; Perelshtein, I; Gedanken, A. “Sonication-Assisted Synthesis of Bimetallic Hg/Pd Alloy Nanoparticles for Catalytic Reduction of Nitrophenol and its Derivatives”. Ultrasonics Sonochemistry, 2020. 60, article number: 104804. • L. Fiandra, P. Bonfantia, Y. Piunno, A. P. Nagvenkar, I. Perelsthein, A. Gedanken, M. Saibene, A. Colombo, P. Mantecca. “Hazard assessment of polymercapped CuO and ZnO nanocolloids: A contribution to the safe-by-design implementation of biocidal agents”. Nanoimpact, 2020. • A. Mukherjee, S. Taragin, H. Aviv, I. Perelshtein, M. Noked. “Rationally Designed Vanadium Pentoxide as High Capacity Insertion Material for Mg-Ion”. Adv. Func. Mat, 2020. 30( 38) Article Number: 2003518. • Ilana Perelshtein, Nina Perkas, Shai Rahimipour and Aharon Gedanken “Bifunctional Carbon Dots—Magnetic and Fluorescent Hybrid Nanoparticles for Diagnostic Applications”. Nanomaterials, 2020, 10, 1384-1391. • Wang, L; Natan, M; Zheng, WS; Zheng, WF; Liu, SQ; Jacobi, G; Perelshtein, I; et.al. “Small molecule-decorated gold nanoparticles for preparing antibiofilm fabrics”. Nanoscale Advances, 2020, 2 (6), 2293-2302. • Konar, R.; Perelshtein, I.; Teblum, E.; et.al. “Scalable Synthesis of Few-Layered 2D Tungsten Diselenide (2H-WSe2) Nanosheets Directly Grown on Tungsten (W) Foil Using Ambient- Pressure Chemical Vapor Deposition for Reversible Li-Ion Storage”. ACS Omega, 2020, 5 (31), 19409-19421. Prof. Popovtzer Rachela Vice Dean Faculty of Engineering Member of BINA Nano-Medicine Center Research Areas • Molecular CT imaging of cancer using targeted gold nanoparticles. • Theranostic approaches for Alzheimer’s and Parkinson’s Diseases. • Metabolic based imaging and therapy. • Optical/chamical imaging of enzymatic activity. • Nanoparticle-based strategies for targeted drug delivery. • In-vivo cell tracking techniques. Abstract Nanotheranostics for Personalized Medicine We strive to develop innovative nanotechnology-based solutions for broad applications, including early diagnosis of disease, targeted drug delivery with reduced side effects, and novel therapeutic approaches. Our vision is to have a major impact on the future of medicine. Our multidisciplinary research approach integrates researchers from the fields of engineering, chemistry, biology and medicine, and consolidates advances in nanomaterials with imaging, specific biomarkers and therapeutics. Molecular CT imaging of cancer using targeted gold nanoparticles Publications 2020 and 2021 • Rui Zhang, Liang Cheng, Ziliang Dong, Linqian Hou, Shaohua Zhang, Zhouqi Meng, Oshra Betzer, Yihua Wang, Rachela Popovtzer, Zhuang Liu. “Ultra-small natural product based coordination

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