61 Prof. Fixler Dror Faculty of Engineering Director of BINA Photonics Center Research Areas • Fluorescence lifetime and anisotropy decay • Fluorescence lifetime imaging (FLIM) • Biological imaging based on fluorescence parameters • Super resolution • Light-tissue interaction Abstract Nano photonics, Fluorescence Imaging and Microscopy Research Fixler’s lab deals with theoretical and practical models for reconstructing the optical properties of participating media by nano photonic tools. Our theory is based on a robust generalization of the diffusion theory; Gerchberg-Saxton algorithm; dipole-dipole approximation and other methods. Onthe practical side we use lasers, LEDs and microscopes. Nanodiamond applied on ex vivo skin samples and penetrated through all skin layers: epidermis, dermis, and fat. Using a non-invasive laser based optical technique we profiled the nanodiamonds’ permeation: the nanodiamonds concentration reduces as the layer is deeper. Publications 2021 and 2022 · Ariel Ashkenazy, Racheli Ron, Tchiya Zar, Hannah Aharon, Adi Salomon, Dror Fixler, Eliahu Cohen. “Measurement of the Second-Order Polarizability of Silver Nanoparticles With Reference-Free Hyper-Rayleigh Scattering for Entangled Photon Pair Interaction”. IEEE Photonics Journal, 2022. · Channa Shapira, Daniel Itshak, Hamootal Duadi, Yifat Harel, Ayelet Atkins, Anat Lipovsky, Ronit Lavi, Jean Paul Lellouche, Dror Fixler. “Noninvasive Nanodiamond Skin Permeation Profiling Using a Phase Analysis Method: Ex Vivo Experiments”. ACS nano, 2022. · Gilad Yahav, Yitzchak Weber, Hamootal Duadi, Shweta Pawar, Dror Fixler. “Classification of fluorescent anisotropy decay based on the distance approach in the frequency domain”. Optics Express, 2022. · Hari Krishna Sadhanala, Sudhakar Pagidi, Suhas Yadav, Marianna Beiderman, Ilya Grinberg, Dror Fixler, Aharon Gedanken. “Boron-doped Carbon Dots with Surface Oxygen Functional Groups as a Highly Sensitive and Labelfree Photoluminescence Probe for the Enhanced Detection of Mg2+ Ions”. ChemistrySelect, 2022. · Nataliia Dudchenko, Shweta Pawar, Ilana Perelshtein, Dror Fixler. “Magnetite Nanoparticles: Synthesis and Applications in Optics and Nanophotonics”. Materials 15 (7), 2601, 2022. · Pavitra Sokke Rudraiah, Hamootal Duadi, Dror Fixler. “Diffused reflectance measurements to detect tattoo ink location in skin using the crossover point”. Journal of Biophotonics, 2022. · Rachel Lubart, Inbar Yariv, Dror Fixler, Anat Lipovsky. “A Novel Facial Cream Based on Skin-penetrable Fibrillar Collagen Microparticles”. J Clin Aesthet Dermatol, 2022. · Rinat Ankri, Dorit Leshem-Lev, Hamootal Duadi, Emanuel Harari, Menachem Motiei, Edith Hochhauser, Eli I Lev, Dror Fixler. “Simultaneous Noninvasive Detection and Therapy of Atherosclerosis Using HDL Coated Gold Nanorods”. Diagnostics, 2022. · Shweta Pawar, Hamootal Duadi, Yafit Fleger, Dror Fixler. “Design and Use of a Gold Nanoparticle–Carbon Dot Hybrid for a FLIM-Based IMPLICATION Nano Logic Gate”. ACS Omega, 2022. · Pavitra S Rudraiah, Hamootal Duadi, Dror Fixler. “Bottom layer absorption coefficients extraction from two-layer phantoms based on crossover point in diffuse reflectance”. Journal of Biomedical Optics, 2021. · Shiran Sudri, Hamootal Duadi, Florin Altman, Irit Allon, Ariel Ashkenazy, Ruchira Chakraborty, Ilya Novikov, Dror Fixler, Abraham Hirshberg. “Diffusion Reflection Method for Early Detection of Oral Squamous Cell Carcinoma Specifically Targeted by Circulating Gold-Nanorods Bio-Conjugated to AntiEpidermal Growth Factor Receptor”. International Journal of Nanomedicine, 2021. · Dror Fixler, Hamootal Duadi, Idit Ferder. “Influence of detector size and positioning on near-infrared measurements and iso-pathlength point of turbid materials”. Frontiers in Physics, 2021. · S.V. Zar’kov, Yu.A. Avetisyan, A.N. Yakunin, I.G. Meerovich, D. Fixler, A.P. Savitsky and V.V. Tuchin. “Interaction of laser radiation and complexes of gold nanoparticles linked with proteins”. Quantum Electronics 51 (1), 52, 2021. · S Pawar, H Duadi, Y Fleger, D Fixler. “Carbon Dots-Based Logic Gates”. Nanomaterials 2021, 11, 232. · Małgorzata Szczerska, Monika Kosowska, Paulina Listewnik, Michał Rycewicz, Mikhael Bechelany, Yafit Fleger, Dror Fixler, Paweł Jakóbczyk. “Diamond protection for reusable ZnO coated fiber-optic measurement head in optoelectrochemical investigation of bisphenol A”. Measurement, 2021. · Haim Feldman, Mark A Iron, Dror Fixler, Sergei Moshkov, Naomi Zurgil, Elena Afrimzon, Mordechai Deutsch. “Fluorophore spectroscopy in aqueous glycerol solution: the interactions of glycerol with the fluorophore”. Photochemical & Photobiological Sciences, 2021. · Marianna Beiderman, Ariel Ashkenazy, Elad Segal, Menachem Motiei, Adi Salomon, Tamar Sadan, Dror Fixler, Rachela Popovtzer. “Optimization of Gold Nanorod Features for the Enhanced Performance of Plasmonic Nanocavity Arrays”. ACS Omega, 2021. · Inbar Yariv, S riram Kannan, Yifat Harel, Esthy Levy, Hamootal Duadi, Jean-Paul Lellouche, Shulamit Michaeli, Dror Fixler. “Iterative optical technique for detecting anti-leishmania nanoparticles in mouse lesions”. Biomedical Optics Express, 2021. · Idit Feder, Hamootal Duadi, Dror Fixler. “Effect of Spatial Modulated Light on Position of Self-Calibration Point”. IEEE Photonics Journal, 2021.
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