68 Dr. Hamo Assaf Department of Physics Member of BINA Electro Magnetism & Spintronics Center Research Areas The Lab for Quantum Imaging Abstract The lab is focused on using quantum sensors for imaging various physical properties at the nanoscale. The two main sensors are a sensor for electric potentials based on carbon nanotubes and a sensor for magnetic fields based on Nitrogen Vacancies (NV) in diamonds. Those sensors have a unique combination of small dimensions and extremely high sensitivity, allowing us to use them for sensing minute fields at the nanoscale. The current projects focus on combining these two unique sensors to overcome many of the limitations of each system. For example, read the NV center’s quantum state using a charge detector made of a carbon nanotube. A second example is using the NV center for probing the electron state on the carbon nanotube with quantum coherence. These projects will pave the way for a quantum imaging technique that probes the quantum nature of a system at the nanoscale. Proposed imaging system of orbital moment of a single electron. A carbon nanotube is suspended between two metallic contacts and above a few metallic gates. A small quantum dot is formed in the center of the carbon nanotube and is populated with a single electron. The electron will circulate clockwise or anti-clockwise depending on the external magnetic field. A diamond tip with a single NV center is brought few tens of nanometers away from the quantum dot. Publications 2021 and 2022 • Qing Hua Wang, Amilcar Bedoya-Pinto, Mark Blei, Avalon H Dismukes, Assaf Hamo, Sarah Jenkins, Maciej Koperski, Yu Liu, Qi-Chao Sun, Evan J Telford, Hyun Ho Kim, Mathias Augustin, Uri Vool, JiaXin Yin, Lu Hua Li, Alexey Falin, Cory R Dean, Fèlix Casanova, Richard FL Evans, Mairbek Chshiev, Artem Mishchenko, Cedomir Petrovic, Rui He, Liuyan Zhao, Adam W Tsen, Brian D Gerardot, Mauro Brotons-Gisbert, Zurab Guguchia, Xavier Roy, Sefaattin Tongay, Ziwei Wang, M Zahid Hasan, Joerg Wrachtrup, Amir Yacoby, Albert Fert, Stuart Parkin, Kostya S Novoselov, Pengcheng Dai, Luis Balicas, Elton JG Santos. “The magnetic genome of two-dimensional van der waals materials”. ACS nano, 2022. • Ziwei Qiu, Uri Vool, Assaf Hamo, Amir Yacoby. “Nuclear spin assisted magnetic field angle sensing”. npj Quantum Information, 2021. • Uri Vool, Assaf Hamo, Georgios Varnavides, Yaxian Wang, Tony X Zhou, Nitesh Kumar, Yuliya Dovzhenko, Ziwei Qiu, Christina AC Garcia, Andrew T Pierce, Johannes Gooth, Polina Anikeeva, Claudia Felser, Prineha Narang, Amir Yacoby. “Imaging phonon-mediated hydrodynamic flow in WTe2”. Nature Physics, 2021. Dr. Hendel Ayal The Mina & Everard Goodman Faculty of Life Sciences Member of BINA Medicine Center Research Areas • Biotechnology • Genetic therapy • Genetic engineering • Developing CRISPR technology as a method of gene therapy for genetic diseases Abstract Precise and efficient CRISPR genome editing as a curative therapy for genetic disorders We are in the midst of a revolution in genome editing and CRISPR-Cas9 technology was the spark. With unprecedented rapidity, this technology has provided a straightforward, robust, and specific method for genome editing. Our research focuses on developing genome editing as curative therapy for genetic diseases and cancer. Our lab is particularly interested in applying genome editing for gene therapy of hematopoietic genetic disorders such as severe combined immunodeficiency (SCID). SCIDs are a set of life threatening genetic diseases in which patients are born with mutations in single genes, and are unable to develop functional immune system. While allogeneic bone marrow transplantation can be curative for these disorders, there remain significant limitations to this approach. We believe that the ultimate cure for these diseases will be transplantation of gene-corrected autologous CD34+ hematopoietic stem and progenitor cells (HSPCs). To be able to apply this approach in the clinic, we must assure that the genome-editing technology is efficient and safe. Hence, our research focuses on developing an optimized CRISPR- genome editing for robust, locusspecific and non-toxic functional gene correction in HSPCs. Additional aspect of our research focuses on applying the Ortal Tiurin, Maria Tkachev, Yair Ein-Eli, Gil Goobes, Boris Markovsky, Doron Aurbach. “Electrochemical and Thermal Behavior of Modified Li and Mn-Rich Cathode Materials in Battery Prototypes: Impact of Pentasodium Aluminate Coating and Comprehensive Understanding of Its Evolution upon Cycling through Solid-State Nuclear Magnetic Resonance Analysis”. Advanced Energy and Sustainability Research, 2021. • Susai Francis Amalraj, Ravikumar Raman, Arup Chakraborty, Nicole Leifer, Raju Nanda, Sooraj Kunnikuruvan, Tatyana Kravchuk, Judith Grinblat, Vladimir Ezersky, Rong Sun, Francis Leonard Deepak, Christoph Erk, Xiaohan Wu, Sandipan Maiti, Hadar Sclar, Gil Goobes, Dan Thomas Major, Michael Talianker, Boris Markovsky, Doron Aurbach. “Boron doped Ni-rich LiNi0.85Co0.10Mn0.05O2 cathode materials studied by structural analysis, solid state NMR, computational modeling, and electrochemical performance”. Energy Storage Materials, 2021. • Ortal Lidor-Shalev, Nicole Leifer, Michal Ejgenberg, Hagit Aviv, Ilana Perelshtein, Gil Goobes, Malachi Noked. “Molecular Layer Deposition of Alucone Thin Film on LiCoO2 to Enable High Voltage Operation”. Batteries & Supercaps, 2021.
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