69 CRISPR technology to treat malignancies using cancer-immunotherapy. Our strategy seeks to improve cancer-fighting potency of human T lymphocytes by genetic modification of immunoreceptors which play a key role during cancer immunity cycle. Publications 2021 and 2022 · A Edri, A Hailu, N Ben Haim, N Brycman, O Berhani-Zipori, J Rifman, S Cohen, D Yackoubov, R Simantov, A Hendel, A Pato, Y Geffen. “GDA-601: NAM-NK CELLS WITH CD38 KNOCKOUT EXPRESSES ENHANCED CD38 CHIMERIC ANTIGEN RECEPTOR AND TARGETS MULTIPLE MYELOMA CELLS WITH INCREASED CYTOTOXICITY”. Cytotherapy, 2022. · Atar Lev, Idan Sharir, Amos J Simon, Shiran Levy, Yu Nee Lee, Shirly Frizinsky, Suha Daas, Talia Saraf-Levy, Arnon Broides, Amit Nahum, Suhair Hanna, Polina Stepensky, Ori Toker, Ilan Dalal, Amos Etzioni, Jerry Stein, Etai Adam, Ayal Hendel, Nufar Marcus, Shlomo Almashanu, Raz Somech. “Lessons Learned from Five Years of Newborn Screening for Severe Combined Immunodeficiency (SCID) in Israel”. The Journal of Allergy and Clinical Immunology: In Practice, 2022. · Ayal Hendel, Ortal Iancu Cohen, Daniel Allen, Orli Knop, Yoni Zehavi, Atar Lev, Yu Nee Lee, Katia Beider, Arnon Nagler, Raz Somech Somech. “Modeling and Correction of RAG2 Severe Combined Immunodeficiency by CRISPR-Cas9 and rAAV6 in Human CD34+ HSPCs”. MOLECULAR THERAPY 30 (4), 272-272, 2022. · Daniel Allen, Lucien E Weiss, Alon Saguy, Michael Rosenberg, Ortal Iancu, Omri Matalon, Ciaran Lee, Katia Beider, Arnon Nagler, Yoav Shechtman, Ayal Hendel. “High-Throughput Imaging of CRISPRand Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells”. The CRISPR Journal, 2022. · Eran Hodis, Elena Torlai Triglia, John YH Kwon, Tommaso Biancalani, Labib R Zakka, Saurabh Parkar, Jan-Christian Hütter, Lorenzo Buffoni, Toni M Delorey, Devan Phillips, Danielle Dionne, Lan T Nguyen, Denis Schapiro, Zoltan Maliga, Connor A Jacobson, Ayal Hendel, Orit Rozenblatt-Rosen, Martin C Mihm Jr, Levi A Garraway, Aviv Regev. “Stepwiseedited, human melanoma models reveal mutations’ effect on tumor and microenvironment”. Science, 2022. · HJ Chung, YK Kang, PD Hsu, S Konermann, MH Porteus, A Hendel, J Clark, RO Bak, Ryan De, DJ Dellinger, R Kaiser, J Myerson, K Gagnon, M Damha, M Habibian, DT O’Reilly, Z Kartje. “CRISPR technology”. Methods, 2022. · J Rifman, N Ben Haim S Cohen N Brycman, A Hailu, O Berhani-Zipori, A Edri, D Yackoubov, R Simantov, A Hendel, A Pato, Y Geffen. “GDA-301: ENGINEERED NAM-NK CELLS VIA CISH KNOCKOUT AND MEMBRANE-BOUND IL-15 EXPRESSION INCREASES CYTOTOXICITY AGAINST MALIGNANCIES”. Cytotherapy, 2022. · Jonathan Molcho, Rivka Manor, Maayan Shamsian, Gurucharan Sudarshan, Rivka Ofir, Danit Parker, Simy Weil, Hanin Wattad, Emily Hayun, Tom Levy, Eliahu D Aflalo, Ayal Hendel, Amir Sagi. “On genome editing in embryos and cells of the freshwater prawn Macrobrachium rosenbergii”. Aquaculture, 2022. · Ori Hassin, Nishanth Belugali Nataraj, Michal Shreberk-Shaked, Yael Aylon, Rona Yaeger, Giulia Fontemaggi, Saptaparna Mukherjee, Martino Maddalena, Adi Avioz, Ortal Iancu, Giuseppe Mallel, Anat Gershoni, Inna Grosheva, Ester Feldmesser, Shifra Ben-Dor, Ofra Golani, Ayal Hendel, Giovanni Blandino, David Kelsen, Yosef Yarden, Moshe Oren. “Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients”. Nature communications, 2022. · A Hendel, I Amit, O Iancu, A LevyJurgenson, G Kurgan, MS McNeill, GR Rettig, D Allen, D Breier, N Ben Haim, Y Wang, L Anavy, Z Yakhini. “CRISPECTOR: an accurate tool for measuring CRISPRCas-induced translocation and adverse off-target activity”. HUMAN GENE THERAPY 32 (19-20), A57-A57, 2021. · Atar Lev, Yu Nee Lee, Guangping Sun, Enas Hallumi, Amos J Simon, Keren S Zrihen, Shiran Levy, Tal Beit Halevi, Maria Papazian, Neta Shwartz, Ido Somekh, Sarina Levy-Mendelovich, Baruch Wolach, Ronit Gavrieli, Helly Vernitsky, Ortal Barel, Elisheva Javasky, Tali Stauber, Chi A Ma, Yuan Zhang, Ninette Amariglio, Gideon Rechavi, Ayal Hendel, Deborah Yablonski, Joshua D Milner, Raz Somech. “Inherited SLP76 deficiency in humans causes Dr. Itzhak Anat HR-SEM, E-SEM, FIB Member of BINA Staff Publications 2021 and 2022 · Anat Itzhak, Xu He, Adi Kama, Sujit Kumar, Michal Ejgenberg, Antoine Kahn, David Cahen. “NiN-Passivated NiO Hole-Transport Layer Improves Halide Perovskite-Based Solar Cell”. ACS Appl. Mater. Interfaces, 2022. · Anat Itzhak, David Keller, Tatyana Bendikov, Adi Kama, Oded Millo, Isaac Balberg, David Cahen. ”Steady-State Optoelectronic Measurements of Halide Perovskites on a Selective Contact: A Path to in Depth Comprehension of Their Photovoltaic Activity”. J. Phys. D Appl. Phys. 55, 455107, 2022. severe combined immunodeficiency neutrophil and platelet defects”. Journal of Experimental Medicine, 2021. · Ido Amit, Ortal Iancu, Alona LevyJurgenson, Gavin Kurgan, Matthew S McNeill, Garrett R Rettig, Daniel Allen, Dor Breier, Nimrod Ben Haim, Yu Wang, Leon Anavy, Ayal Hendel, Zohar Yakhini. “CRISPECTOR provides accurate estimation of genome editing translocation and off-target activity from comparative NGS data”. Nature communications, 2021. · Ido Somekh, Atar Lev, Ortal Barel, Yu Nee Lee, Ayal Hendel, Amos J Simon, Raz Somech. “Exploring genetic defects in adults who were clinically diagnosed as severe combined immune deficiency during infancy”. Immunologic Research, 2021. · Daniel Allen, Michael Rosenberg, Ayal Hendel. “Using synthetically engineered guide RNAs to enhance CRISPR genome editing systems in mammalian cells”. Frontiers in Genome Editing, 2021. · Jenny Shapiro, Adi Tovin, Ortal Iancu, Daniel Allen, Ayal Hendel. “Chemical modification of guide RNAs for improved CRISPR activity in CD34+ human hematopoietic stem and progenitor cells”. CRISPR Guide RNA Design, 37-48, 2021.
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