76 Prof. Mandel Yossi The Mina & Everard Goodman Faculty of Life Sciences Member of BINA Medicine Center Research Areas Ophthalmic Science and Engineering Lab • Electro-cellular interfaces, optical and electronic micro-devices development • Applied science for improving diagnosis, treatment and prevention of various ophthalmicdiseases. Talianker, Dan Thomas Major, Doron Aurbach. “Enhancement of Structural, Electrochemical, and Thermal Properties of High-Energy Density Ni-Rich LiNi0.85Co0.1Mn0.05O2 Cathode Materials for Li-Ion”. ACS Applied Materials & Interfaces, 2021. · Yehonatan Levartovsky, Sooraj Kunnikuruvan, Arup Chakraborty, SANDIPAN MAITI, Judith Grinblat, Michael Talianker, Dam Thomas Major, Doron Aurbach. “Electrochemical and Structural Studies of LiNi0.85Co0.1Mn0.05O2, a Cathode Material for High Energy Density Li-Ion Batteries, Stabilized by Doping with Small Amounts of Tungsten”. Journal of The Electrochemical Society, 2021. · Shani Zev, Keren Raz, Renana Schwartz, Reem Tarabeh, Prashant Kumar Gupta, Dan T Major. “Benchmarking the Ability of Common Docking Programs to Correctly Reproduce and Score Binding Modes in SARS-CoV-2 Protease Mpro”. Journal of chemical information and modeling, 2021. · Severin Merget, Lorenzo Catti, Shani Zev, Dan T Major, Nils Trapp, Konrad Tiefenbacher. “Concentration-dependent Self-assembly of an Unusually Large Hexameric Hydrogen-bonded Molecular Cage”. Chemistry–A European Journal, 2021. · Anil R Mhashal, Dan Thomas Major. “Temperature-Dependent Kinetic Isotope Effects in R67 Dihydrofolate Reductase from Path-Integral Simulations”. The Journal of Physical Chemistry B, 2021. • Artificial introduction of the visual information and its processing by the retina and the visual cortex. • Electro-cellular interface with the autonomic system and application of high electrical field for solid tumor ablation (IRE - Irreversible Electroporation). Abstract Our lab is pursuing several strategies for vision restoration in people with degenerative diseases of the outer retina. The main focus is the development of the hybrid retinal implant (HRI) which combines electrical and cell replacement therapy approaches for vision restoration. The HRI concept relies on the coupling of glutamtergic cells with electrodes situated at the bottom of an insulating microwells , and their integration with host retina following subretinal implantation. The realization of this concepts entails many fields, from stem cells through neural engineering to electrode and device fabrication using advanced nanotechnology. Retinal implant with photoreceptor precursors integrated within microwells. Publications 2021 and 2022 · Ariel Halevi, Nairouz Farah, Nisan Ozana, Sharon Cohen, Assaf Shoval, Orit Shefi, Yossi Mandel, Zeev Zalevsky. “Remote photonic sensing of action potential in mammalian nerve cells via histogrambased analysis of temporal spatial acoustic vibrations”. Optics Express, 2022. · Nairouz Farah, Efrat Simon, Yossi Mandel. “Investigating the survival and function of retinal ganglion cells in an organotypic culture: An in-vitro model for studying synaptogenesis”. Investigative Ophthalmology & Visual Science, 2022. · Ori Carmi, Adi Gross, Nadav Ivzan, Lamberto La Franca, Nairouz Farah, Zeev Zalevsky, Yossi Mandel. “Evaluation and Optimization of Methods for Generating High-Resolution Retinotopic Maps Using Visual Cortex Voltage-Sensitive Dye Imaging”. Frontiers in Cellular Neuroscience, 2021. · amar Arens-Arad, Rivkah Lender, Nairouz Farah, Yossi Mandel. “Cortical responses Prof. Margel Shlomo Department of Chemistry Member of BINA Nano & Advanced Materials Center Medicine Center Research Areas · Polymers & biopolymers · Surface chemistry · Thin films · Nanotechnology, Nabiotechnology and agro-nanotechnology · Encapsulation · Applications of magnetic and nonmagnetic functional nanoparticles for medical (specific cell labeling and separation · Diagnosis and therapy of cancer · Controlled release · Multimodal contrast agents · Wound healing · Neurodegenerative disorders, etc · Agricultural and industrial applications, PVA/PVP Hydrogels for controlled release in industrial and medical applications Abstract Polymers, biopolymers and nanotechnology for biomedical and industrial applications Prof. Margel’s earlier interests included electrochemistry of vinylic monomers and polymers, polyaldehyde microspheres and self-assembly monolayers. His current research focuses on functional polymeric nano/micro-particles for medical and industrial applications, such as targeted nanocapsule drug delivery systems, surface modification, and functional thin coatings (self-cleaning, anti-biofouling, UV absorbers, anti-fog and superhydrophobic coatings). He is a world pioneer and gained international reputation in the area of nanotechnology, particularly in the design of functional nano/micro particles of very to prosthetic retinal stimulation are significantly affected by the light-adaptive state of the surrounding normal retina”. Journal of Neural Engineering, 2021.
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