2022 ANNUAL REPORT

86 The Copper cellular cycle in A. human cell. B. in E. coli cell. Publications 2021 and 2022 · Adi Yahalom, Hadassa Shaked, Sharon Ruthstein, Jordan H Chill. “Inherent Minor Conformer of Bordetella Effector BteA Directs Chaperone-Mediated Unfolding”. Journal of the American Chemical Society, 2022. · Gil Otis, Denial Aias, Ilya Grinberg, Sharon Ruthstein, Yitzhak Mastai. “Probing Chirality of Crystals using Electron Paramagnetic Resonance (EPR) spectroscopy”. 2022. · Gulshan Walke, Jana Aupič, Hadeel Kashoua, Pavel Jano , Shelly Meron, Yulia Shenberger, Zena Qasem, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein. “Dynamical interplay between the human highaffinity copper transporter hCtr1 and its cognate metal ion”. Biophysical Journal, 2022. · Idan Yakobov, Alysia Mandato, Lukas Hofmann, Kevin Singewald, Yulia Shenberger, Lada Gevorkyan-Airapetov, Sunil Saxena, Sharon Ruthstein. “Allostery-driven changes in dynamics regulate the activation of bacterial copper transcription factor”. Protein Science, 2022. · Ira Litvak, Haim Cohen, Sharon Ruthstein, Yaakov Anker, Avner Cahana. “The effects of thermal treatment and irradiation on the chemical properties of natural diamonds”. Physical Chemistry Chemical Physics, 2022. · Joshua Casto, Alysia Mandato, Lukas Hofmann, Idan Yakobov, Shreya Ghosh, · Ilan Hakimi, Naor Vardi, Amos Sharoni, Michael Rosenbluh, Yosef Yeshurun. “Enhancement of photon detection in superconducting nanowire single photon detector exposed to oscillating magnetic field”. Applied Physics Letters, 2021. Prof. Ruthstein Sharon Department of Chemistry Member of BINA Electro Magnetism & Spintronics Center Medicine Center Nano & Advanced Materials Center Research Areas • plasmonics • molecules-surface plasmons interaction • molecular dynamics • strong coupling systems • Near field spectroscopy • Second Harmonic Generation (SHG) Abstract Biomolecular EPR Spectroscopy lab Our work focuses on the cellular copper cycle. The knowledge gained by studying the copper cycle in eukaryotic and prokaryotic systems is then used to develop new biomarkers and therapeutic agents that are dependent on the copper cycle. We believe that a basic understanding of the chemical and biological systems is essential for developing the next generation of biomarkers and drugs that will be adopted in the clinic. Our group utilizes various spectroscopic (specifically EPR spectroscopy) and computational methods to resolve cellular metal transfer mechanisms in vitro and in cells at the molecular level. Moreover, when a therapeutic or diagnostic compound is developed (based on the knowledge gained in the lab), all experiments until the mouse stage (included) are performed in house by my group members. Sharon Ruthstein, Sunil Saxena. “Cu (II)-based DNA Labeling Identifies the Structural Link Between Activation and Termination in a Metalloregulator”. Chemical Science, 2022. · Pavel Jano , Jana Aupič, Sharon Ruthstein, Alessandra Magistrato. “The conformational plasticity of the selectivity filter methionines controls the in-cell Cu (I) uptake through the CTR1 transporter”. QRB Discovery, 2022. · Shelly Meron, Yulia Shenberger, Sharon Ruthstein. “The Advantages of EPR Spectroscopy in Exploring Diamagnetic Metal Ion Binding and Transfer Mechanisms in Biological Systems”. Magnetochemistry 8 (1), 3, 2022. · Renana Schwartz, Sharon Ruthstein, Dan Thomas Major. “Molecular Dynamics Simulations of the Apo and Holo States of the Copper Binding Protein CueR Reveal Principal Bending and Twisting Motions”. The Journal of Physical Chemistry B, 2021. · Tze’ela Taub, Sharon Ruthstein, Haim Cohen. “Thermal Stability of CarbonCentered Radicals Involved in LowTemperature Oxidation of Bituminous and Lignite Coals as a Function of Temperature”. ACS Omega, 2021. · Ira Litvak, Haim Cohen, Yaakov Anker, Sharon Ruthstein. “Nitrogen concentration and anisotropic effects on the EPR spectra of natural diamonds”. CrystEngComm, 2021. · Abderrahim Moumen, Rajashree Konar, Dario Zappa, Eti Teblum, Ilana Perelshtein, Ronit Lavi, Sharon Ruthstein, Gilbert Daniel Nessim, Elisabetta Comini. “Robust Room-Temperature NO2 Sensors from Exfoliated 2D Few-Layered CVD-Grown Bulk Tungsten Di-selenide (2H-WSe2)”. ACS Appl. Mater. Interfaces 2021, 13, 3, 4316–4329. · Madina Telkhozhayeva, Rajashree Konar, Ronit Lavi, Eti Teblum, Bibhudatta Malik, Sharon Ruthstein, Elisa Moretti, Gilbert Daniel Nessim. “Phase-Dependent Photocatalytic Activity of Bulk and Exfoliated Defect-Controlled Flakes of Layered Copper Sulfides under Simulated Solar Light”. ACS Sustainable Chemistry & Engineering, 2021. · Olav Schiemann, Caspar A Heubach, Dinar Abdullin, Katrin Ackermann, Mykhailo Azarkh, Elena G Bagryanskaya, Malte Drescher, Burkhard Endeward, Jack H Freed, Laura Galazzo, Daniella Goldfarb, Tobias Hett, Laura Esteban Hofer, Luis Fabregas Ibanez, Eric J Hustedt, Svetlana Kucher, Ilya Kuprov, Janet Eleanor Lovett, Andreas Meyer ,Sharon Ruthstein, Sunil Saxena, Stefan Stoll,Christiane R Timmel,Marilena Di Valentin, Hassane S Mchaourab, Thomas F Prisner, Bela

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