68 using cancer-immunotherapy. Our strategy seeks to improve cancer-fighting potency of human T lymphocytes by genetic modification of immunoreceptors which play a key role during cancer immunity cycle. Paradigmof genomeediting for gene therapy of severe combined immunodeficiency. Publications 2022 and 2023 • Ayal Hendel, Rasmus O Bak. “CRISPR and beyond: Cutting-edge technologies for gene correction in therapeutic applications”. Frontiers in Genome Editing, 2023. • Daniel Allen, Orli Knop, Bryan Itkowitz, Ortal Iancu, Katia Beider, Yu Nee Lee, Arnon Nagler, Raz Somech, Ayal Hendel. “CRISPR-Cas9 RAG2 Correction via Coding Sequence Replacement to Preserve Endogenous Gene Regulation and Locus Structure”. Research Square, 2023. • Daniel Allen, Nechama Kalter, Michael Rosenberg, Ayal Hendel. ”HomologyDirected-Repair-Based Genome Editing in HSPCs for the Treatment of Inborn Errors of Immunity and Blood Disorders”. Pharmaceutics, 2023. • Ortal Iancu, Daniel Allen, Orli Knop, Yonathan Zehavi, Dor Breier, Adaya Arbiv, Atar Lev, Yu Nee Lee, Katia Beider, Arnon Nagler, Raz Somech, Ayal Hendel. “Multiplex HDR for disease and correction modeling of SCID by CRISPR genome editing in human HSPCs”. Molecular Therapy-Nucleic Acids, 2023. • Dana Peleg-Chen, Guy Shuvali, Lev Brio, Amit Ifrach, Ortal Iancu, Efrat BarbiroMichaely, Ayal Hendel, Doron Gerber. “Microfluidic tool for rapid functional characterization of CRISPR complexes”. New Biotechnology, 2022. • A Hendel, O Iancu Cohen, D Allen, O Knop, Y Zehavi, A Lev, YN Lee, K Beider, A Nagler, R Somech. “Multiplex HDR for Modeling and Correction of RAG2 Severe Combined Immunodeficiency by CRISPRGenome Editing in Human CD34+ HSPCs”. Human Gene Therapy, 2022. • A Edri, A Hailu, N Ben Haim, N Brycman, O Berhani-Zipori, J Rifman, S Cohen, D Yackoubov, R Simantov, A Hendel, A Pato, Y Geffen. “GDA-601: NAM-NK Cells with CD38 Knockout Expresses Enhanced CD38 Chimeric Antigen Receptor and Tragets Multiple Myeloma Cells with Increased Cytotoxicity”. Cytotherapy, 2022. • Atar Lev, Idan Sharir, Amos J Simon, Shiran Levy, Yu Nee Lee, Shirly Frizinsky, Suha Daas, Talia Saraf-Levy, Arnon Broides, Amit Nahum, Suhair Hanna, Polina Stepensky, Ori Toker, Ilan Dalal, Amos Etzioni, Jerry Stein, Etai Adam, Ayal Hendel, Nufar Marcus, Shlomo Almashanu, Raz Somech. “Lessons Learned from Five Years of Newborn Screening for Severe Combined Immunodeficiency (SCID) in Israel”. The Journal of Allergy and Clinical Immunology: In Practice, 2022. • Ayal Hendel, Ortal Iancu Cohen, Daniel Allen, Orli Knop, Yoni Zehavi, Atar Lev, Yu Nee Lee, Katia Beider, Arnon Nagler, Raz Somech Somech. “Modeling and Correction of RAG2 Severe Combined Immunodeficiency by CRISPR-Cas9 and rAAV6 in Human CD34+ HSPCs”. Molecular Therapy, 2022. • Daniel Allen, Lucien E Weiss, Alon Saguy, Michael Rosenberg, Ortal Iancu, Omri Matalon, Ciaran Lee, Katia Beider, Arnon Nagler, Yoav Shechtman, Ayal Hendel. “High-Throughput Imaging of CRISPRand Recombinant Adeno-Associated Virus–Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells”. The CRISPR Journal, 2022. • Eran Hodis, Elena Torlai Triglia, John YH Kwon, Tommaso Biancalani, Labib R Zakka, Saurabh Parkar, Jan-Christian Hütter, Lorenzo Buffoni, Toni M Delorey, Devan Phillips,Danielle Dionne, Lan T Nguyen, Denis Schapiro, Zoltan Maliga, Connor A Jacobson,Ayal Hendel, Orit Rozenblatt-Rosen, Martin C Mihm Jr,Levi A Garraway, Aviv Regev. “Stepwiseedited, human melanoma models reveal mutations’ effect on tumor and microenvironment”. Science, 2022. • HJ Chung, YK Kang, PD Hsu, S Konermann, MH Porteus, A Hendel, J Clark, RO Bak, Ryan De, DJ Dellinger, R Kaiser, J Myerson, K Gagnon, M Damha, M Habibian, DT O’Reilly, Z Kartje. “CRISPR technology”. Methods, 2022. • J Rifman, N Ben Haim S Cohen N Brycman, A Hailu, O Berhani-Zipori, A Edri, D Yackoubov, R Simantov, A Hendel, A Pato, Y Geffen. “GDA-301: Engineered NAM-NK Cells Via Cish Knockout and Membrane Bound IL-15 Expression Increases Cytotoxicity against Malignancies”. Cytotherapy, 2022. • Jonathan Molcho, Rivka Manor, Maayan Shamsian, Gurucharan Sudarshan, Rivka Ofir, Danit Parker,Simy Weil,Hanin Wattad, Emily Hayun, Tom Levy, Eliahu D Aflalo, Ayal Hendel, Amir Sagi. “On genome editing in embryos and cells of the freshwater prawn Macrobrachium rosenbergii”. Aquaculture, 2022. • Ori Hassin, Nishanth Belugali Nataraj, Michal Shreberk-Shaked, Yael Aylon, Rona Yaeger, Giulia Fontemaggi, Saptaparna Mukherjee, Martino Maddalena, Adi Avioz, Ortal Iancu, Giuseppe Mallel, Anat Gershoni, Inna Grosheva, Ester Feldmesser, Shifra Ben-Dor, Ofra Golani, Ayal Hendel, Giovanni Blandino, David Kelsen, Yosef Yarden, Moshe Oren. “Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients”. Nature communications, 2022. Dr. Itzhak Anat HR-SEM, E-SEM, FIB Member of BINA Staff Publications 2022 and 2023 • Gindi, O., Fradkin, Z., Itzhak, A., Beker, P. “Lowering the Temperature and Increasing the Fill Factor of Silicon Solar Cells by Filtering of Sub-Bandgap Wavelengths”. Energies, 2023. • Kumar, S., Damle, V. H., Bendikov, T., Itzhak, A., Elbaum, M., Rechav, K., Houben, L., Tischler, D. and Cahen, D. “Topotactic, Vapor-Phase, in situ Monitored Formation of Ultra-thin, Phase-Pure 2D-on-3D Halide Perovskite Surfaces”. ACS Appl. Mater. Interfaces, 2023. • Halder, A., Itzhak, A., Rosh Hodesh, E., Tirosh, T., Cahen, D.. “Surface Interactions of Oxygen Suffice to P-Dope the Halide Perovskites”. Adv. Mater. Interfaces, 2022. • Kama, A., Tirosh, S., Itzhak, A., Ejgenberg, M., and Cahen, D. “New Pb-Free Stable Sn–Ge Solid Solution Halide Perovskites Fabricated by Spray Deposition”. ACS Appl. Energy Mater, 2022. • Bodenstein-Dresler, L., Kama, A., Frisch, J., Hartmann, C., Itzhak, A., Wilks, R. G.,
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