71 Publications 2022 and 2023 • Julia Malinovskaya, Rawan Salami, Marat Valikhov, Veronika Vadekhina, Aleksey Semyonkin, Alevtina Semkina, Maxim Abakumov, Yifat Harel, Esthy Levy, Tzuriel Levin, Rachel Persky, Vladimir Chekhonin, Jean-Paul Lellouche, Pavel Melnikov, Svetlana Gelperina. “Supermagnetic Human Serum Albumin (HSA) Nanoparticles and PLGA-Based Doxorubicin Nanoformulation: A Duet for Selective Nanotherapy”. International Journal of Molecular Sciences, 2022. • Channa Shapira, Daniel Itshak, Hamootal Duadi, Yifat Harel, Ayelet Atkins, Anat Lipovsky, Ronit Lavi, Jean Paul Lellouche, Dror Fixler. “Noninvasive Nanodiamond Skin Permeation Profiling Using a Phase Analysis Method: Ex Vivo Experiments”. ACS nano, 2022. • M Wacker, F Wetterling, T Feczko, K Arkelius, A Arnou, J Lellouche, S Ansar. “Advanced theranostic nanocarriermediated delivery of NGF in a combination therapy trigger enhanced recovery after stroke”. Journal of Cerebral Blood Flow and Metabolism, 2022. Publications 2022 and 2023 • Julian Schütt, Hariharan Nhalil, Jürgen Fassbender, Lior Klein, Asaf Grosz, Denys Makarov. “Modular Droplet-Based Fluidics for Large Volume Libraries of Individual Multiparametric Codes in Lab-On-Chip Systems”. Advanced Sensor Research, 2023. • Hariharan Nhalil, Daniel Lahav, Moty Schultz, Shai Amrusi, Asaf Grosz, Lior Klein. “Flexible planar Hall effect sensor with sub-200 pT resolution”. Applied Physics Letters, 2023. • Hariharan Nhalil, Moty Schultz, Shai Amrusi, Asaf Grosz, Lior Klein. “Parallel array of planar Hall effect sensors for high resolution magnetometry”. Journal of Applied Physics, 2023. • Ariel Zaig, Shubhankar Das, Moty Shultz, Lior Klein. “Giant response to spin-orbit torques in heavy-metal/ferromagnetic bilayers associated with magnetic reversal”. Physical Review B, 2022. • Hariharan Nhalil, Moty Schultz, Shai Amrusi, Asaf Grosz, Lior Klein. “High Sensitivity Planar Hall Effect Magnetic Field Gradiometer for Measurements in Millimeter Scale Environments”. Micromachines, 2022. Prof. Lellouche Jean-Paul Department of Chemistry Member of BINA Nano & Advanced Materials Center Nano-Biomedicine Center Research Areas • Functional electroconductive polymers (ECPs) and nano/microparticle fabrication - Functionalization/nanostructuration of polymeric films • Magnetically-responsive composite polymer-nanoparticles for ultrasensitive detection of DNA hybridization and drug release using combinatorial approaches • ECPs-microarrays for diagnostics • ECPs-biosensors/immunosensors • High-throughput screening of polymersupported chiral catalysts • (1,3)-dienyliron-carbonyl complexes in asymmetric synthesis • Selective deprotective chemistries ofOSiR3 ethers mediated by VilsmeierHaack reagents (kinetic resolutions/ deracemizations of meso compounds) • Functionalization of carbon nanotubes et use in self assembling systems/ composites materials • Polymodal silica and silicon carbide nanoparticles for hard surfaces and their mode of functionalization using ECPs Abstract Innovative Surface Engineering of Magnetic/Non-Magnetic Nanomaterials (Functional Inorganic TMDC Nanotubes, Nano-Diamonds (NDs) and Maghemite NPs for Gene Silencing, Photodynamic/ Photothermal Therapies, & Anti-Parasitic Bio-Activity) In our lab, we focused on both synthesis of functionalized magnetic NPs and surface modification/engineering of both tungsten disulfide nanotubes and NanoDiamonds. These set of functional NPs are nontoxic/biocompatible and has a high potential as drug delivery systems, with an important capability of imaging (MRI, X-ray, Fluorescence, … etc.). So far, we focused on the following topics, the use of magnetically responsive NPs in cooperation with Photodynamic Therapy (PDT) drug towards higher drug accumulation by magnetic targeting and therefore, a much more effective PDT output. We also developed an effective innovative nanoscale Delivery System as anti-Leishmania drug, which is based on cerium cation/ complex-doped maghemite nanoparticles (Ce·ɣ-Fe 2O3-NPs) that are coordinatively bound by both polyethylenemine (PEI) polymer and FDA-approved antileishmanial drug pentamidine. Novel surface engineering of nanodiamonds has been also innovatively discovered towards a preliminary wide range of biological and cosmetic applications. Moreover, novel functionalization of inorganic WS2 nanotubes with maghemite NPs resulted in an hybrid magnetic nanocomposite to improve anti-cancer treatment using photothermal therapy (PTT), as well as promoting nanomaterial reduced aggregation together with an additional ability for nanotube versatile second-step surface functionality/engineering.
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