72 Prof. Levanon Erez The Mina & Everard Goodman Faculty of Life Science Member of BINA Nano-Biomedicine Center Nano & Advanced Materials Center Research Areas Genomics Research Abstract We study the dynamics of genetic information, and how it affects disease, evolution and, behavior. Specifically, we develop technology and algorithms to uncover the full extent of A- to-I RNA editing in human and animal models. We are also develop technology to manipulate the genomic information by recruiting endogenous cellular RNA editing processes. Pre-mRNA molecules transcribed from the genome may fold form double-stranded RNA structures. ADAR enzymes bind these structures and deaminate some adenosines to inosines. If these inosines are located in an exon, they will be present in the mature mRNA. Publications 2022 and 2023 • Miriam Karmon, Eli Kopel, Aviv Barzilai, Polina Geva, Eli Eisenberg, Erez Y Levanon, Shoshana Greenberger. “Altered RNA Editing in Atopic Dermatitis Highlights the Role of Double-Stranded RNA for Immune Surveillance”. Journal of Investigative Dermatology, 2023. • Rona Merdler-Rabinowicz, David Gorelik, Jiwoon Park, Cem Meydan, Jonathan Foox, Miriam Karmon, Hillel S Roth, Roni Cohen-Fultheim, Galit ShohatOphir, Eli Eisenberg, Eytan Ruppin, Christopher E Mason, Erez Y Levanon. “Elevated A-to-I RNA editing in COVID-19 infected individuals”. NAR Genomics and Bioinformatics, 2023. • Gwendoline Astre, Tehila Atlan, Uri Goshtchevsky, Adi Oron-Gottesman, Margarita Smirnov, Kobi Shapira, Ariel Velan, Joris Deelen, Tomer Levy, Erez Y Levanon, Itamar Harel. “Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate”. Developmental Cell, 2023. • Adi Avram-Shperling, Eli Kopel, Itamar Twersky, Orshay Gabay, Amit BenDavid, Sarit Karako-Lampert, Joshua JC Rosenthal, Erez Y Levanon, Eli Eisenberg, Shay Ben-Aroya. “Identification of exceptionally potent adenosine deaminases RNA editors from high body temperature organisms”. PLoS Genetics, 2023. • Tomer D Mann, Eli Kopel, Eli Eisenberg, Erez Y Levanon. “Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies”. PLOS Computational Biology, 2023. • Amina Jbara, Kuan-Ting Lin, Chani Stossel, Zahava Siegfried, Haya Shqerat, Adi Amar-Schwartz, Ela Elyada, Maxim Mogilevsky, Maria Raitses-Gurevich, Jared L Johnson, Tomer M Yaron, Ofek Ovadia, Gun Ho Jang, Miri Danan-Gotthold, Lewis C Cantley, Erez Y Levanon, Steven Gallinger, Adrian R Krainer, Talia Golan, Rotem Karni. “RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer”. Nature, 2023. • Dror Sharon, Nina Schneider, Johanna Valensi, Ricky Steinberg, Amit Eylon, Eyal Banin, Erez Levanon, Shay Ben-Aroya. “RNA editing of mutations causing inherited retinal diseases using the cellular deaminase acting on RNA (ADAR) enzyme”. Investigative Ophthalmology & Visual Science, 2023. • Florian Szymczak, Roni Cohen-Fultheim, Sofia Thomaidou, Alexandra Coomans de Brachène, Angela Castela, Maikel Colli, Piero Marchetti, Erez Levanon, Decio Eizirik, Arnaud Zaldumbide. “ADAR1dependent editing regulates human β cell transcriptome diversity during inflammation”. Frontiers in Endocrinology, 2022. • L Moyal, M Karmon, E Levanon, E Hodak. “Elevated A-to-I RNA editing in leukemic cutaneous T-cell lymphoma”. European Journal of Cancer, 2022. • Nina Schneider, Yogapriya Sundaresan, Prakadeeswari Gopalakrishnan, Avigail Beryozkin, Mor Hanany, Erez Y Levanon, Eyal Banin, Shay Ben-Aroya, Dror Sharon. “Inherited retinal diseases: linking genes, disease-causing variants, and relevant therapeutic modalities”. Progress in Retinal and Eye Research, 2022. • Warhaftig Gal, Sokolik Chaya Mushka, Khermesh Khen, Lichtenstein Yehuda, Barak Michal, Bareli Tzofnat, Erez Y Levanon, Yadid Gal. ”RNA editing of the 5-HT2C receptor in the central nucleus of the amygdala is involved in resilience behavior”. Translational Psychiatry, 2022. • Hugh S Gannon, Tao Zou, Michael K Kiessling, Galen F Gao, Diana Cai, Peter S Choi, Alexandru P Ivan, Ilana Buchumenski, Ashton C Berger, Jonathan T Goldstein, Andrew D Cherniack, Francisca Vazquez, Aviad Tsherniak, Erez Y Levanon, William C Hahn, Matthew Meyerson. “Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells”. Nature Communications, 2022. • Nina Schneider, Ricky Steinberg, Johanna Valensi, Amit Eylon, Eyal Banin, Erez Levanon, Shay Ben-Aroya, Dror Sharon. “RNA Editing of Israeli Founder Nonsense Mutations causing IRDs using SiteDirected Adenosine Deaminase Acting on RNA”. Investigative Ophthalmology & Visual Science, 2022. • Orshay Gabay, Yoav Shoshan, Eli Kopel, Udi Ben-Zvi, Tomer D Mann, Noam Bressler, Roni Cohen-Fultheim, Amos A Schaffer, Shalom Hillel Roth, Ziv Tzur, Erez Y Levanon, Eli Eisenberg. “Landscape of adenosine-to-inosine RNA recoding across human tissues”. Nature Communications, 2022. • Tomer Mann, Eli Eisenberg, Erez Levanon. “PO-675-08 AG RNA Editing as A Mediator of Atrial Fibrillation”. Heart Rhythm, 2022.
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