75 • Electro-cellular interface with the autonomic system and application of high electrical field for solid tumor ablation (IRE - Irreversible Electroporation). Abstract Our lab is pursuing several strategies for vision restoration in people with degenerative diseases of the outer retina. The main focus is the development of the hybrid retinal implant (HRI) which combines electrical and cell replacement therapy approaches for vision restoration. The HRI concept relies on the coupling of glutamtergic cells with electrodes situated at the bottom of an insulating microwells , and their integration with host retina following subretinal implantation . The realization of this concepts entails many fields, from stem cells through neural engineering to electrode and device fabrication using advanced nanotechnology. Retinal implant with photoreceptor precursors integrated within microwells. Publications 2022 and 2023 • Auria Eisen-Enosh, Nairouz Farah, Uri Polat, Yossi Mandel. ” Temporal Synchronization Elicits Enhancement of Binocular Vision Functions”. iScience, 2023. • Gal Shpun, Nairouz Farah, Yoav Chemla, Amos Markus, Doron Gerber, Zeev Zalevsky, Yossi Mandel. “Fabrication of a 3D high-resolution implant for neural stimulation-challenges and solutions”. Research Square, 2022. • Ariel Halevi, Nairouz Farah, Nisan Ozana, Sharon Cohen, Assaf Shoval, Orit Shefi, Yossi Mandel, Zeev Zalevsky. “Remote photonic sensing of action potential in mammalian nerve cells via histogrambased analysis of temporal spatial acoustic vibrations”. Optics Express, 2022. • Nairouz Farah, Efrat Simon, Yossi Mandel. “Investigating the survival and function of retinal ganglion cells in an organotypic culture: An in-vitro model for studying synaptogenesis”. Investigative Ophthalmology & Visual Science, 2022. Prof. Margel Shlomo Department of Chemistry Member of BINA Nano & Advanced Materials Center Nano-Biomedicine Center Research Areas: • Polymers & biopolymers • Surface chemistry • Thin films • Nanotechnology, Nabiotechnology and agro-nanotechnology • Encapsulation • Applications of magnetic and nonmagnetic functional nanoparticles for medical (specific cell labeling and separation • Diagnosis and therapy of cancer Controlled release • Multimodal contrast agents • Wound healing • Neurodegenerative disorders, etc.) • Agricultural and industrial applications, PVA/PVP Hydrogels for controlled release in industrial and medical applications Abstract Polymers, biopolymers and nanotechnology for biomedical and industrial applications Professor Margel is a polymer chemist whose main interest lies in the fields of Polymers & biopolymers; Surface chemistry; Thin films; Nanotechnology, nanobiotechnology and agro-nanotechnology; Encapsulation; Applications of magnetic and non-magnetic functional nanoparticles for medical (specific cell labeling and separation, diagnosis and therapy of cancer, controlled release, multimodal contrast agents, wound healing, neurodegenerative disorders, etc.), agricultural and industrial applications, Functional hydrogels for controlled release in agricultural and medical applications. He has published some 350 publications, has been awarded 56 patents, author of a few chapters in several books, wrote 2 books, and granted 80 national and international grants. 111 students already completed their graduate studies under his supervision. h factor: 56, Citations: 11,900. TEM images illustrating cellular uptake of P(RGD)/Pal,Alp(50%) NCs by HCT116 colon cancer cells after incubation for 2, 5, 10, and 24 h (A–D, respectively). Green arrow (B), accumulation of NCs in the cytoplasm; yellow arrow (B), unclustered NCs; blue arrow (C), NCs in vesicles; red arrow (D), collagen fibers; M-l/M-d, live/ dead mitochondria. Scale bars represent 2 µm (left) and 500 nm (right). E) Uptake of NCs by engulfing at 2 h: NCs attached to a) outer and b,c) inner cell membrane, d) pinched off, released inside the cells, characterized by membrane (white arrow), e) empty vesicle (lysosome), and f) NCs within vesicle with membrane (white arrow). Inset shows 4× magnification. F) Schematic illustration of internalization showing NC engulfment and pinching off. Itzhaki, Ella, et al. "Tumor-Targeted Poly (ArgGlyAsp) Nanocapsules for Personalized Cancer Therapy–In-vivo Study." Advanced Therapeutics (2023): 2200337.
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