77 reputation in these fields, and have pioneered several new concepts and techniques in the following areas: SAM’s for the preparation of Chiral Nanosurfaces for Chiral resolution by crystallization. Chiral ordered Mesoporous silica by Chiral polymer -Templated Synthesis. An innovative new Carbon Chiral Mesoporous, based on the Carbonization of Chiral Ionic liquids. The development of Optical Scanning Microscopy (NSOM) and Isothermal Titration Calorimetry (ITC) for the determination of Nanoscale Chirality. HE-TEM images of Chiral Titania (TiO2) nanofilms. Publications 2022 and 2023 • Ganit Indech, Lidor Geri, Chen Mordechai,Y arden Ben Moshe, Yitzhak Mastai, Orit Shefi, Amos Sharoni. “Controlled synthesis of multifunctional dome-shaped micro-and nano-structures via a robust physical route for biological applications”. Journal of Materials Chemistry B, 2023. • Matan Oliel, Yitzhak Mastai. “Isothermal Titration Calorimetry: The Heat of Dilution, Racemization, and What Lies In Between”. Preprints, 2023. • Michal Ejgenberg, Yitzhak Mastai. “L-Glu Hierarchical Structure Crystallization Using Inorganic Ions”. Crystals, 2023. • Meir Abuaf, Subhomoy Das, Yitzhak Mastai. “Organocatalytic chiral polymeric nanoparticles for asymmetric aldol reaction”. RSC advances, 2023. • Ori Licht, Darío Barreiro-Lage, Patrick Rousseau, Alexandre Giuliani, Aleksandar R Milosavljević, Avinoam Isaak, Yitzhak Mastai, Amnon Albeck, Raj Singh, Vy TT Nguyen, Laurent Nahon, Lara MartínezFernández, Sergio Díaz-Tendero,Yoni Toker. “Peptide Bond Formation in the Protonated Serine Dimer Following Vacuum UV Photon-Induced Excitation”. Angewandte Chemie, 2023. • Adi Azoulay, Sapir Shekef Aloni, Lidan Xing, Ayelet Tashakory, Yitzhak Mastai, Menny Shalom. “Polymeric Carbon nitride with chirality inherited from supramolecular assemblies”. Angewandte Chemie International Edition, 2023. • Akmaral B Rakhym, Zarina Ye Baranchiyeva, Aruzhan K Kenessova, Bagashar B Zhaksybai, Diana N Dauzhanova, Yitzhak Mastai, Gulziya A Seilkhanova. “Recyclable Adsorbents for Potash Brine Desalination Based on Silicate Powder: Application, Regeneration and Utilization”. Colloids and Interfaces, 2023. • Meir Abuaf, Yitzhak Mastai. “Electrospinning of polymer nanofibers based on chiral polymeric nanoparticles”. Polymers for Advanced Technologies, 2022. • Reut Yemini, Shalev Blanga, Hagit Aviv, Ilana Perelshtein, Eti Teblum, Shahar Dery, Elad Gross, Yitzhak Mastai, Malachi Noked, Ortal Lidor-Shalev. “Growth of Hybrid Chiral Thin Films by Molecular Layer Deposition Zinc/Cysteine as a Case Study”. Advanced Materials Interfaces, 2022. • Sapir Shekef Aloni, Molhm Nassir, Yitzhak Mastai. “Chiral Porous Carbon Surfaces for Enantiospecific Synthesis”. Polymers, 2022. • Subhomoy Das, Alexander V Butenko, Yitzhak Mastai, Moshe Deutsch, Eli Sloutskin. “Topology-driven surface patterning of liquid spheres”. Nature Physics, 2022. • Liroy Lugasi, Gil Otis, Matan Oliel, Shlomo Margel, Yitzhak Mastai. “Chirality of proteinoid nanoparticles made of lysine and phenylalanine”. Polymers for Advanced Technologies, 2022. • Gil Otis, Denial Aias, Ilya Grinberg, Sharon Ruthstein, Yitzhak Mastai. “Probing Chirality of Crystals using Electron Paramagnetic Resonance (EPR) spectroscopy”. Research Square, 2022. Prof. Michaeli Shulamit Vice President for Research The Mina & Everard Goodman Faculty of Life Sciences Member of BINA Nano-Biomedicine Center Nano-Bioconvergence Center Research Areas • Mechanism and machinery of nucleolar gene silencing • The use of nanoparticles for cytoplasmic and nuclear gene silencing • Trans-splicing in trypanosomatids • Protein translocation in trypanosomatids • RNA modifications mediated by guide RNAs • RNAi silencing in plants • The use of nano particles as RNAi carriers into the nucleous Publications 2022 and 2023 • Fabien Guegan, K Shanmugha Rajan, Fábio Bento, Daniel Pinto-Neves, Mariana Sequeira, Natalia Gumińska, Seweryn Mroczek, Andrzej Dziembowski, Smadar Cohen-Chalamish, Tirza Doniger, Beathrice Galili, Antonio M Estévez, Cedric Notredame, Shulamit Michaeli, Luisa M Figueiredo. “A long noncoding RNA promotes parasite differentiation in African trypanosomes”. Science Advances, 2022. • Hari Krishna Sadhanala, Saurav Aryal, Kusha Sharma, Ziv Orpaz, Shulamit Michaeli, Aharon Gedanken. “Nitrogendoped carbon dots as a highly selective and sensitive fluorescent probe for sensing Mg2+ ions in aqueous solution, and their application in the detection and imaging of intracellular Mg2+ ions”. Sensors and Actuators B: Chemical, 2022. • K Shanmugha Rajan, Katerina Adler, Tirza Doniger, Smadar Cohen-Chalamish, Noa Aharon-Hefetz, Saurav Aryal, Yitzhak Pilpel, Christian Tschudi, Ron Unger, Shulamit Michaeli. “Identification and functional implications of pseudouridine RNA modification on small noncoding RNAs in the mammalian pathogen Trypanosoma brucei”. Journal of Biological Chemistry, 2022. • Laura Piel, K Shanmugha Rajan, Giovanni Bussotti, Hugo Varet, Rachel Legendre, Caroline Proux, Thibaut Douché, Quentin Giai-Gianetto, Thibault Chaze,Thomas Cokelaer, Barbora Vojtkova, Nadav Gordon-Bar, Tirza Doniger, Smadar Cohen-Chalamish, Praveenkumar Rengaraj, Céline Besse, Anne Boland, Jovana Sadlova, Jean-François Deleuze, Mariette Matondo, Ron Unger, Petr Volf, Shulamit Michaeli, Pascale Pescher, Gerald F Späth. “Experimental evolution links post-transcriptional regulation to Leishmania fitness gain”. PLoS pathogens, 2022. • Nofar Atari, K Shanmugha Rajan, Vaibhav Chikne, Smadar Cohen-Chalamish, Tirza Doniger, Odelia Orbaum, Avi Jacob, Inna Kalt, Shulamit Michaeli, Ronit Sarid. “Lytic reactivation of the Kaposi’s sarcoma-associated herpesvirus (KSHV) is accompanied by major nucleolar alterations”. Viruses, 2022.
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