79 • Bibhudatta Malik, Hari Krishna Sadhanala, Rong Sun, Francis Leonard Deepak, Aharon Gedanken, Gilbert Daniel Nessim. “Co3O4|CoP Core–Shell Nanoparticles with Enhanced Electrocatalytic Water Oxidation Performance”. ACS Applied Nano Materials, 2022. • Bibhudatta Malik, Hari Krishna Sadhanala, Rong Sun, Francis Leonard Deepak, Aharon Gedanken, Gilbert Daniel Nessim. “Co3O4 vertical bar CoP CoreShell Nanoparticles with Enhanced Electrocatalytic Water Oxidation Performance”. ACS Applied Nano Materials, 2022. • Bibhudatta Malik, Hari Krishna Sadhanala, SK Tarik Aziz, Sumit Majumder, Rajashree Konar, Aharon Gedanken, Gilbert Daniel Nessim. “Synergy between Cobalt– Chromium-Layered Double Hydroxide Nanosheets and Oxidized Carbon Nanotubes for Electrocatalytic Oxygen Evolution”. ACS Applied Nano Materials, 2022. • Bibhudatta Malik, Sumit Majumder, Roberto Lorenzi, Ilana Perelshtein, Michal Ejgenberg, Alberto Paleari, Gilbert Daniel Nessim. "Promising Electrocatalytic Water and Methanol Oxidation Reaction Activity by Nickel Doped Hematite/Surface Oxidized Carbon Nanotubes Composite Structures”. ChemPlusChem, 2022. • Madina Telkhozhayeva, Baruch Hirsch, Rajashree Konar, Eti Teblum, Ronit Lavi, Michal Weitman, Bibhudatta Malik, Elisa Moretti, Gilbert Daniel Nessim. “2D TiS2 Flakes for Tetracycline Hydrochloride Photodegradation under Solar Light”. Applied Catalysis B: Environmental, 2022. • Pola Shriber, Maria Tkachev, Ayelet Atkins, Ilana Perelshtein, Sharon Bretler, Bruria Schmerling, Gino Mariotto, Marco Giarola, Yafit Fleger, Gilbert Daniel Nessim. “Synthesis of nickel sulfide dendrites from nickel foil using thermal annealing”. Materialia, 2022. • Rajashree Konar, Bharathi Rajeswaran, Atanu Paul, Eti Teblum, Hagit Aviv, Ilana Perelshtein, Ilya Grinberg, Yaakov Raphael Tischler, Gilbert Daniel Nessim. “CVDAssisted Synthesis of 2D Layered MoSe2 on Mo Foil and Low Frequency Raman Scattering of Its Exfoliated Few-Layer Nanosheets on CaF2 Substrates”. ACS Omega, 2022. • Rajashree Konar, Gilbert Daniel Nessim. “A mini-review focusing on ambientpressure chemical vapor deposition (APCVD) based synthesis of layered transition metal selenides for energy storage applications”. Materials Advances, 2022. • Rajashree Konar, Rimon Tamari, Eti Teblum, Gilbert Daniel Nessim, Louisa Meshi. “In-depth characterization of stacking faults forming during the growth of Transition-Metal Di-Chalcogenides (TMDCs) by ambient pressure-CVD”. Materials Characterization, 2022. • Sandipan Maiti, Rajashree Konar, Hadar Sclar, Judith Grinblat, Michael Talianker, Maria Tkachev, Xiaohan Wu, Aleksandr Kondrakov, Gilbert Daniel Nessim, Doron Aurbach. “Stabilizing High-Voltage Lithium-Ion Battery Cathodes Using Functional Coatings of 2D Tungsten Diselenide”. ACS Energy Letters, 2022. Prof. Nir Uri The Mina & Everard Goodman Faculty of Life Sciences Member of BINA Nano-Biomedicine Center Research Areas Molecular biology of cancer Abstract Targeting selectively the energy generation system of cancer cells The aspiration to achieve efficacious cancer targeted therapy involves intense global R&D efforts. Blockage of fundamental processes like the unique and reprogramed energy generation system of malignant cells should offer new tools for efficient interference with cancer progression. While deciphering the energy generation system of cancer cells we identified an enzyme termed- FerT, which normally resides only in the energy power-station (termed mitochondria) of sperm cells, and is harnessed by cancer cells to empower their reprogrammed mitochondria. We found that FerT potentiates the generation of energy by mitochondria in cancer cells in general and in metastatic cells (cells which leave the primary tumor and are spreading throughout the patient’s body) in particular, thereby enabling them to survive under stress conditions like nutrient and oxygen deprivation. This supports the survival of metastatic cancer cells under harsh conditions which they encounter during their dissemination throughout the patient’s body. To translate these findings into a novel anti-cancer therapy we have combined, synthetic-chemistry, robotic, and high throughput screening approaches, for the development of a synthetic low molecular weight compound which binds and inhibits the activity of the FerT enzyme. Our lead compound called E260 targets and inhibits FerT in the power station- mitochondria of malignant cells, thereby selectively imposing energy crisis and consequent death of cancer cells in general and metastatic cells in particular. Since metastatic spreading of malignant cells throughout the patient’s body is the main cause of death from cancer, our findings portray E260 as a new, potential and promising anti-cancer drug. The above described findings were published in the high profile journal Nature communication: Elkis, Y., Cohen, M., Yaffe, E., Feldman, T., Satmary, S., Nyska, A., Shpungin, S., and Nir, U. (2017) A Fer/ FerT targeting compound selectively evokes metabolic stress and necrotic death in malignant cells. Nature Comm. DOI:10.1038/s41467-017-00832-w Deformation and destruction of the mitochondria (energy power station) of metastatic cancer cells (indicated by blue arrows the right panels which represent two magnification) by the newly developed anti-cancer agent-E260. Publications 2022 and 2023 • Uri Nir, Elina Grinshtain, Haim Breitbart. “Fer and FerT: A New Regulatory Link between Sperm and Cancer Cells”. International Journal of Molecular Sciences, 2023. • Elina Grinshtain, Sally Shpungin, Micha Baum, Uri Nir, Haim Breitbart. “The Fer tyrosine kinase protects sperm from spontaneous acrosome reaction”. Developmental Biology, 2022. Untreated cancer cell Cancer cell treated with E260
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