84 developed (based on the knowledge gained in the lab), all experiments until the mouse stage (included) are performed in house by my group members. The Copper cellular cycle in A. human cell. B. in E. coli cell. Publications 2022 and 2023 • Yulia Shenberger, Lada Gevorkyan Aiapetov, Melanie Hirsch, Lukas Hofmann, Sharon Ruthstein. “An in-cell spinlabelling methodology provides structural information on cytoplasmic proteins in bacteria”. Chemical Communications, 2023. • Melanie Hirsch, Lukas Hofmann, Yulia Shenberger, Lada Gevorkyan-Airapetov, Sharon Ruthstein. “Conformations and Local Dynamics of the CopY Metal Sensor Revealed by EPR Spectroscopy”. Biochemistry, 2023. • Kevin Singewald, Hannah Hunter, Timothy F Cunningham, Sharon Ruthstein, Sunil Saxena. “Measurement of protein dynamics from site directed Cu (II) labeling”. Analysis & Sensing, 2023. • Yasmin Igbaria-Jaber, Lukas Hofmann, Lada Gevorkyan-Airapetov, Yulia Shenberger, Sharon Ruthstein. “Revealing the DNA Binding Modes of CsoR by EPR Spectroscopy”. ACS Omega, 2023. • Renana Schwartz, Sharon Ruthstein, Dan Thomas Major. “Copper coordination states affect the flexibility of copper Metallochaperone Atox1: Insights from molecular dynamics simulations”. Protein Science 2022. • Zena Qasem, Matic Pavlin, Ida Ritacco, Matan Y Avivi, Shelly Meron, Melanie Hirsch, Yulia Shenberger, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein. “Disrupting Cu trafficking as a potential therapy for cancer”. Frontiers in Molecular Biosciences, 2022. • Lukas Hofmann, Sharon Ruthstein. “EPR Spectroscopy Provides New Insights into Complex Biological Reaction Mechanisms”. The Journal of Physical Chemistry B, 2022. • Ira Litvak, Avner Cahana, Yaakov Anker, Sharon Ruthstein, Haim Cohen. “Nitrogen Structure Determination in Treated Fancy Diamonds via EPR Spectroscopy”. Crystals, 2022. • L Hofmann, A Mandato, S Saxena, S Ruthstein. “The use of EPR spectroscopy to study transcription mechanisms”. Biophysical Reviews, 2022. • Adi Yahalom, Hadassa Shaked, Sharon Ruthstein, Jordan H Chill. “Inherent Minor Conformer of Bordetella Effector BteA Directs Chaperone-Mediated Unfolding”. Journal of the American Chemical Society, 2022. • Gil Otis, Denial Aias, Ilya Grinberg, Sharon Ruthstein, Yitzhak Mastai. “Probing Chirality of Crystals using Electron Paramagnetic Resonance (EPR) spectroscopy”. 2022. • Gulshan Walke, Jana Aupič, Hadeel Kashoua, Pavel Janoš, Shelly Meron, Yulia Shenberger, Zena Qasem, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein. “Dynamical interplay between the human highaffinity copper transporter hCtr1 and its cognate metal ion”. Biophysical Journal, 2022. • Idan Yakobov, Alysia Mandato, Lukas Hofmann, Kevin Singewald, Yulia Shenberger, Lada Gevorkyan-Airapetov, Sunil Saxena, Sharon Ruthstein. “Allostery-driven changes in dynamics regulate the activation of bacterial copper transcription factor”. Protein Science, 2022. • Ira Litvak, Haim Cohen, Sharon Ruthstein, Yaakov Anker, Avner Cahana. “The effects of thermal treatment and irradiation on the chemical properties of natural diamonds”. Physical Chemistry Chemical Physics, 2022. • Joshua Casto, Alysia Mandato, Lukas Hofmann, Idan Yakobov, Shreya Ghosh, Sharon Ruthstein, Sunil Saxena. “Cu (II)-based DNA Labeling Identifies the Structural Link Between Activation and Termination in a Metalloregulator”. Chemical Science, 2022. • Pavel Janoš, Jana Aupič, Sharon Ruthstein, Alessandra Magistrato. “The conformational plasticity of the selectivity filter methionines controls the in-cell Cu (I) uptake through the CTR1 transporter”. QRB Discovery, 2022. • Shelly Meron, Yulia Shenberger, Sharon Ruthstein. “The Advantages of EPR Spectroscopy in Exploring Diamagnetic Metal Ion Binding and Transfer Mechanisms in Biological Systems”. Magnetochemistry, 2022. Prof. Salomon Adi Department of Chemistry Member of BINA Nano-Photonics Center Nano & Advanced Materials Center Research Areas • plasmonics • molecules-surface plasmons interaction • molecular dynamics • strong coupling systems • Near field spectroscopy • Second Harmonic Generation (SHG) Abstract Light-matter interaction at the nanoscale The overall goal of my laboratory is to develop, fabricate and to use plasmonic systems as a ‘photonic environment’, or even as a ‘photonic catalyst’. In general, we aim at opening new routes for photochemical processes/ reactions on surfaces by controlling the electromagnetic-field properties at the metal surface, that is, to do, ‘chemistry with plasmons’. Large-scale nonporous metallic network is belong to a unique class of light materials with photocatalytic and optical properties which we develop in my lab.
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